ArticleJournal of bacteriology2009
Pilin antigenic variation occurs independently of the RecBCD pathway in Neisseria gonorrhoeae.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Type IV minor pilin ComN predicted the USS-receptor in Pasteurellaceae.Frontiers in microbiology · 2025Article
- Pilin antigenic variants impact gonococcal lifestyle and antibiotic tolerance by modulating interbacterial forces.PLoS biology · 2025Article
- A Double-Strand Break Does Not Promote Neisseria gonorrhoeae Pilin Antigenic Variation.Journal of bacteriology · 2019Article
- Analysis of Pilin Antigenic Variation in Neisseria meningitidis by Next-Generation Sequencing.Journal of bacteriology · 2018Article
- Initiation of homologous recombination at DNA nicks.Nucleic acids research · 2018Review
- Does DNA replication direct locus-specific recombination during host immune evasion by antigenic variation in the African trypanosome?Current genetics · 2017Review
- Analyzing Neisseria gonorrhoeae Pilin Antigenic Variation Using 454 Sequencing Technology.Journal of bacteriology · 2016Article
- Mobile DNA in the pathogenicMicrobiology spectrum · 2015Article
- The use of high-throughput DNA sequencing in the investigation of antigenic variation: application to Neisseria species.PloS one · 2014Article
- The nucleotide excision repair system of Borrelia burgdorferi is the sole pathway involved in repair of DNA damage by UV light.Journal of bacteriology · 2013Article
- Suggested role for G4 DNA in recombinational switching at the antigenic variation locus of the Lyme disease spirochete.PloS one · 2013Article
- Microbial antigenic variation mediated by homologous DNA recombination.FEMS microbiology reviews · 2012Review
- Inhibition of IL-10 production by maternal antibodies against Group B Streptococcus GAPDH confers immunity to offspring by favoring neutrophil recruitment.PLoS pathogens · 2011Article
- Focusing homologous recombination: pilin antigenic variation in the pathogenic Neisseria.Molecular microbiology · 2011Review
- Article
- The Neisseria gonorrhoeae photolyase orthologue phrB is required for proper DNA supercoiling but does not function in photo-reactivation.Molecular microbiology · 2011Article
- DNA uptake sequence-mediated enhancement of transformation in Neisseria gonorrhoeae is strain dependent.Journal of bacteriology · 2010Article
- Frequency and rate of pilin antigenic variation of Neisseria meningitidis.Journal of bacteriology · 2010Article
- Mismatch correction modulates mutation frequency and pilus phase and antigenic variation in Neisseria gonorrhoeae.Journal of bacteriology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Type IV pilus expression has been strongly implicated in the virulence of Neisseria gonorrhoeae, the causative agent of gonorrhea. In Neisseria, these pili undergo frequent antigenic variation (Av), which is presumed to allow reinfection of high-risk groups. Pilin Av is the result of RecA-mediated recombination events between the gene encoding the major pilin subunit (pilE) and multiple silent pilin locus (pilS) copies, utilizing a RecF-like recombination pathway. The role of RecBCD in pilin Av has been controversial. Previous studies measuring pilin Av in recB and recD mutants in two independent strains of N. gonorrhoeae (MS11 and FA1090) by indirect methods yielded conflicting results. In addition, these two laboratory strains have been suggested to express very different DNA repair capabilities. We show that the FA1090 and MS11 parental strains have similar abilities to repair DNA damage via UV-induced DNA damage, nalidixic acid-induced double-strand breaks, and methyl methanesulfonate-induced alkylation and that RecB and RecD are involved in the repair of these lesions. To test the role of the RecBCD pathway in pilin Av, the rate and frequency of pilin Av were directly measured by sequencing the pilE locus in randomly selected piliated progeny of both MS11 and FA1090 in recB and recD mutants. Our results definitively show that recB and recD mutants undergo pilin Av at rates similar to those of the parents in both strain backgrounds, demonstrating that efficient pilin Av is neither enhanced nor inhibited by the RecBCD complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.