ArticlePsychosomatic medicine2009
Association of salivary cortisol circadian pattern with cynical hostility: multi-ethnic study of atherosclerosis.
Article in Psychosomatic medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Psychosocial functioning and the cortisol awakening response: Meta-analysis, P-curve analysis, and evaluation of the evidential value in existing studies.Biological psychology · 2017Pooled it
- A pilot randomized controlled trial of mindfulness-based stress reduction for caregivers of family members with dementia.Aging & mental health · 2016Trial
- Hostile attitudes and effortful coping in young adulthood predict cognition 25 years later.Neurology · 2016Article
- Depressive Mood, Anger, and Daily Cortisol of Caregivers on High- and Low-Stress Days.The journals of gerontology. Series B, Psychological sciences and social sciences · 2015Article
- Relationships between inflammatory cytokine and cortisol responses in firefighters exposed to simulated wildfire suppression work and sleep restriction.Physiological reports · 2015Article
- Association of Sleep Duration and Quality With Alterations in the Hypothalamic-Pituitary Adrenocortical Axis: The Multi-Ethnic Study of Atherosclerosis (MESA).The Journal of clinical endocrinology and metabolism · 2015Article
- Hostility and physiological responses to acute stress in people with type 2 diabetes.Psychosomatic medicine · 2015Article
- Variability and reliability of diurnal cortisol in younger and older adults: implications for design decisions.Psychoneuroendocrinology · 2014Article
- Associations of socioeconomic and psychosocial factors with urinary measures of cortisol and catecholamines in the Multi-Ethnic Study of Atherosclerosis (MESA).Psychoneuroendocrinology · 2014Article
- Relationship between the cortisol awakening response and other features of the diurnal cortisol rhythm: the Multi-Ethnic Study of Atherosclerosis.Psychoneuroendocrinology · 2013Article
- Daytime trajectories of cortisol: demographic and socioeconomic differences--findings from the National Study of Daily Experiences.Psychoneuroendocrinology · 2013Article
- A day-centered approach to modeling cortisol: diurnal cortisol profiles and their associations among U.S. adults.Psychoneuroendocrinology · 2013Article
- Blunted nocturnal cortisol rise is associated with higher carotid artery intima-media thickness (CIMT) in overweight African American and Latino youth.Psychoneuroendocrinology · 2013Article
- Diurnal salivary cortisol is associated with body mass index and waist circumference: the Multiethnic Study of Atherosclerosis.Obesity (Silver Spring, Md.) · 2013Article
- Modeling the salivary cortisol profile in population research: the multi-ethnic study of atherosclerosis.American journal of epidemiology · 2012Article
- Associations of salivary cortisol levels with inflammatory markers: the Multi-Ethnic Study of Atherosclerosis.Psychoneuroendocrinology · 2012Article
- Diurnal salivary cortisol and urinary catecholamines are associated with diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis.Metabolism: clinical and experimental · 2012Article
- Social strain and cortisol regulation in midlife in the US.Social science & medicine (1982) · 2012Article
- Associations of salivary cortisol levels with metabolic syndrome and its components: the multi-ethnic study of atherosclerosis.The Journal of clinical endocrinology and metabolism · 2011Article
- Reliability of hypothalamic-pituitary-adrenal axis assessment methods for use in population-based studies.European journal of epidemiology · 2011Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine if cynical hostility is associated with alterations in diurnal profiles of cortisol. Hostility has been linked to cardiovascular disease but the biological mechanisms mediating this association remain unknown.
methodsUp to 18 measures of salivary cortisol taken over 3 days were obtained from each of 936 participants in the Multi-Ethnic Study of Atherosclerosis (MESA). Cynical hostility was measured using an eight-item subscale of the Cook-Medley Hostility Scale. Cortisol profiles were modeled using regression spline models that incorporated random parameters for subject-specific effects. Models were adjusted for race, sex, age, socioeconomic position, and lifestyle factors. The association of cynical hostility with key features of the cortisol diurnal profile, both in the full sample and important subsamples, was examined.
resultsWaking cortisol levels as well as the extent of the morning surge in cortisol levels did not differ significantly across tertiles of cynical hostility. Respondents in the lowest tertile of cynical hostility experienced a 22% sharper decline in salivary cortisol (age- and sex-adjusted slope of -0.49 microg/dL per hour) than respondents in the highest tertile (-0.40 microg/dL per hour, p for difference = .0004). Intertertile differences in these parameters remained unaltered after further adjustment for potential confounders. This pattern of differences in cortisol diurnal profile tended to be related in a dose-response way to level of cynical hostility, and persisted in stratified analyses.
conclusionsCynical hostility is associated with the declining phase of the awakening cortisol response. The implications of this for cardiovascular and other health outcomes remain to be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.