ArticleThe journal of pain2009
Acidic saline-induced primary and secondary mechanical hyperalgesia in mice.
Article in The journal of pain, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Can Myofascial Trigger Points Involve Nociplastic Pain? A Scoping Review on Animal Models.Journal of pain research · 2023Article
- Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models.International journal of molecular sciences · 2022Article
- Long-lasting reflexive and nonreflexive pain responses in two mouse models of fibromyalgia-like condition.Scientific reports · 2022Article
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- Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update.International journal of molecular sciences · 2021Review
- Properties and Differential Expression of HFrontiers in physiology · 2021Review
- A role for neuroimmune signaling in a rat model of Gulf War Illness-related pain.Brain, behavior, and immunity · 2021Article
- Acid-sensing ion channels in sensory signaling.American journal of physiology. Renal physiology · 2020Review
- Regular physical activity prevents development of chronic muscle pain through modulation of supraspinal opioid and serotonergic mechanisms.Pain reports · 2017Article
- Neurobiology of fibromyalgia and chronic widespread pain.Neuroscience · 2016Review
- Consistent sex-dependent effects of PKMζ gene ablation and pharmacological inhibition on the maintenance of referred pain.Molecular pain · 2016Article
- ASICs Mediate Pain and Inflammation in Musculoskeletal Diseases.Physiology (Bethesda, Md.) · 2015Review
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- Animal models of fibromyalgia.Arthritis research & therapy · 2013Review
- ASICs Do Not Play a Role in Maintaining Hyperalgesia Induced by Repeated Intramuscular Acid Injections.Pain research and treatment · 2012Article
- Vitamin D deficiency promotes skeletal muscle hypersensitivity and sensory hyperinnervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Changes in intramuscular cytokine levels during masseter inflammation in male and female rats.Neuroscience letters · 2011Article
- Primary somatosensory cortex in chronic low back pain - a H-MRS study.Journal of pain research · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledMost of our knowledge about chronic musculoskeletal pain is based on cutaneous pain models. To test the hypothesis that animals develop chronic muscular hyperalgesia following intramuscular acidic saline injections, primary hyperalgesia within the gastrocnemius muscle was analyzed compared to secondary cutaneous hyperalgesia in the hind paw that develops following intramuscular acid saline injection. Two acidic saline (pH 4) injections were administrated into the gastrocnemius of female CF-1 mice. The results indicate that mice developed a robust hypersensitivity bilaterally in primary (gastrocnemius muscle) secondary (cutaneous hind paw) sites that lasted up to 2 weeks. In addition, primary hyperalgesia correlated well with levels of Fos expression. Fos expression patterns in the spinal cord were different for primary secondary site stimulation. Hind-paw palpation stimulated ipsilateral Fos expression in the superficial spinal laminae at L4/L5 levels, bilaterally in deep laminae at L2-L5 spinal levels. In contrast, gastrocnemius compression stimulated widespread Fos expression in all regions of the ipsilateral dorsal horn within L2-L6 spinal segments. These findings indicate that acidic saline injection induces primary hyperalgesia in muscle that the patterns of Fos expression in response to primary vs secondary stimulation are strikingly different. PERSPECTIVE: This study assesses primary site muscular pain, which is the main complaint of people with musculoskeletal conditions, and identifies spinal patterns activated by noxious mechanical stimuli to the gastrocnemius. This study demonstrates approaches to test nociception arising from muscle aids in our understanding of spinal processing of primary secondary site hyperalgesia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.