ArticleThe Journal of infectious diseases2009
Proteinuria, creatinine clearance, and immune activation in antiretroviral-naive HIV-infected subjects.
Article in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Safety and tolerability of the ACE-inhibitor lisinopril among Nigerian adults with HIV: preliminary pilot data from a randomized clinical trial.Naunyn-Schmiedeberg's archives of pharmacology · 2026Trial
- Atorvastatin reduces T-cell activation and exhaustion among HIV-infected cART-treated suboptimal immune responders in Uganda: a randomised crossover placebo-controlled trial.Tropical medicine & international health : TM & IH · 2015Trial
- High dose atorvastatin decreases cellular markers of immune activation without affecting HIV-1 RNA levels: results of a double-blind randomized placebo controlled clinical trial.The Journal of infectious diseases · 2011Trial
- Microalbuminuria in Perinatally HIV-Infected Children and Adolescents in the United States.Open forum infectious diseases · 2023Article
- Etiology of Persistent Microalbuminuria in Nigeria (P_MICRO study): protocol and study design.BMC infectious diseases · 2022Article
- Apolipoprotein-1 risk variants and associated kidney phenotypes in an adult HIV cohort in Nigeria.Kidney international · 2021Article
- Article
- Markers of renal disease and function are associated with systemic inflammation in HIV infection.HIV medicine · 2015Article
- Relationships between renal parameters and serum and urine markers of inflammation in those with and without HIV infection.AIDS research and human retroviruses · 2015Article
- Proteinuria is associated with neurocognitive impairment in antiretroviral therapy treated HIV-infected individuals.Journal of acquired immune deficiency syndromes (1999) · 2014Observational
- Prevalence of proteinuria and elevated serum cystatin C among HIV-Infected Adolescents in the Reaching for Excellence in Adolescent Care and Health (REACH) study.Journal of acquired immune deficiency syndromes (1999) · 2012Article
- Risk factors for chronic kidney disease in a large cohort of HIV-1 infected individuals initiating antiretroviral therapy in routine care.AIDS (London, England) · 2012Article
- Worsening endothelial function with efavirenz compared to protease inhibitors: a 12-month prospective study.PloS one · 2012Article
- A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.Nature genetics · 2011Article
- Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension.The Journal of infectious diseases · 2011Article
- Renal issues in HIV infection.Current HIV/AIDS reports · 2011Review
Corrections and comments
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Authors and funding
9 authors at 9 institutions in 1 country.
Funding
Abstract
Because both renal disease and immune activation predict progression to acquired immunodeficiency syndrome (AIDS), we evaluated the associations between proteinuria>or=1+, as determined by dipstick analysis (7 [7%] of 1012 subjects); creatinine clearance of <90 mL/min (195 [18%] of 1071 subjects); and percentages of peripheral activated CD8 cells (CD8+CD38+HLA-DR+ cells) in antiretroviral-naive, human immunodeficiency virus (HIV)-infected subjects who were enrolled in AIDS Clinical Trials Group studies 384 and A5095. Proteinuria, but not creatinine clearance, was associated with higher percentages of CD8+CD38+HLA-DR+ cells (55% vs. 50%; P=.01), with even more pronounced differences noted among men and among blacks and Hispanics. Proteinuria may be a surrogate measurement of greater immune activation in HIV-infected patients initiating antiretroviral therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.