ArticleBiomacromolecules2009
Self-assembled hydrogels from poly[N-(2-hydroxypropyl)methacrylamide] grafted with beta-sheet peptides.
Article in Biomacromolecules, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Hydrophilic biomaterials: From crosslinked and self-assembled hydrogels to polymer-drug conjugates and drug-free macromolecular therapeutics.Journal of controlled release : official journal of the Controlled Release Society · 2024Article
- Biomaterials via peptide assembly: Design, characterization, and application in tissue engineering.Acta biomaterialia · 2022Review
- Self-Healing, Self-Assembled β-Sheet Peptide-Poly(γ-glutamic acid) Hybrid Hydrogels.Journal of the American Chemical Society · 2017Article
- Hybrid polymeric hydrogels via peptide nucleic acid (PNA)/DNA complexation.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- POLYMERIC BIOMATERIALS AND NANOMEDICINES.Journal of drug delivery science and technology · 2015Article
- Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine.Progress in polymer science · 2014Article
- Smart self-assembled hybrid hydrogel biomaterials.Angewandte Chemie (International ed. in English) · 2012Review
- Hybrid hydrogels self-assembled from graft copolymers containing complementary β-sheets as hydroxyapatite nucleation scaffolds.Biomaterials · 2011Article
- Assembly Properties of an Alanine-Rich, Lysine-Containing Peptide and the Formation of Peptide/Polymer Hybrid Hydrogels.Macromolecular chemistry and physics · 2011Article
- Biomaterials and drug delivery: past, present, and future.Molecular pharmaceutics · 2010Article
- Synthesis and characterization of enzymatically degradable PEG-based peptide-containing hydrogels.Macromolecular bioscience · 2010Article
- HPMA copolymers: origins, early developments, present, and future.Advanced drug delivery reviews · 2010Article
- HYDROGELS FROM SOFT CONTACT LENSES AND IMPLANTS TO SELF-ASSEMBLED NANOMATERIALS.Journal of polymer science. Part A, Polymer chemistry · 2009Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
A new hybrid hydrogel based on poly[N-(2-hydroxypropyl)methacrylamide] grafted with a beta-sheet peptide, Beta11, was designed. Circular dichroism spectroscopy indicated that the folding ability of beta-sheet peptide was retained in the hybrid system, whereas the sensitivity of the peptide toward temperature and pH variations was hindered. The polymer backbone also prevented the twisting of the fibrils that resulted from the antiparallel arrangement of the beta-strands, as proved by Fourier transform infrared spectroscopy. Thioflavin T binding experiments and transmission electron microscopy showed fibril formation with minimal lateral aggregation. As a consequence, the graft copolymer self-assembled into a hydrogel in aqueous environment. This process was mediated by association of beta-sheet domains. Scanning electron microscopy revealed a particular morphology of the network characterized by long-range order and uniformly aligned lamellae. Microrheology results confirmed that concentration-dependent gelation occurred.
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