ArticleInternational urology and nephrology2010
The clearance of unidentified uremic solutes (with molecular weight under 5 kDa) plays an important role in hemodialyzer selection.
Article in International urology and nephrology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe purpose of this study was to evaluate two commercial hemodialyzers (F100 and P21) through the clearance of identified and unidentified uremic solutes.
methodsWe investigated plasma samples from healthy and uremic subjects.
resultsWe found three unidentified uremic solutes (P1, P2, and P3) after HPLC analysis of plasma samples. Then, we determined the clearance of four identified and the three unidentified uremic solutes in patients with F100 and P21. There was no significance between F100 and P21 in clearance of four identified uremic solutes. By contrast, the clearance of P1 and P2 with F100 was superior with the P21 (P < 0.05).
conclusionOur data suggest that selection of a hemodialyzer based on the clearance of identified uremic solutes might not be sufficient. Application of external techniques to determine additional external factors (i.e., clearance of unidentified uremic solutes) can facilitate a better decision in the selection of the ideal hemodialyzer.
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