ArticleJournal of clinical biochemistry and nutrition2009
F(2)-isoprostanes as novel biomarkers for type 2 diabetes: a review.
Article in Journal of clinical biochemistry and nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Comparative evaluation of oxidative stress biomarkers F2-isoprostanes and 8-OHdG in Parkinson's disease and Type 2 Diabetes Mellitus: a systematic review and meta-analysis of human studies.Annals of medicine · 2026Pooled it
- The Promising Role of Microbiome Therapy on Biomarkers of Inflammation and Oxidative Stress in Type 2 Diabetes: A Systematic and Narrative Review.Frontiers in nutrition · 2022Pooled it
- Impact of Dairy Intake on Plasma FNutrients · 2021Trial
- Review
- Lifestyle intervention is associated with attenuation of ER stress/inflammation and enhancement of naive immune cell identity in older adults with metabolic disease.bioRxiv : the preprint server for biology · 2026Article
- F2-Isoprostanes Are Associated With Increased Fracture Risk in Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2025Observational
- Urinary thromboxane and isoprostane levels are elevated in symptom-high T2-biomarker-low severe asthma.ERJ open research · 2025Article
- Upper airway microcirculation remodeling in obstructive sleep apnea is not driven by endothelial activation.Scientific reports · 2025Article
- Review
- Nutritional load in post-prandial oxidative stress and the pathogeneses of diabetes mellitus.NPJ science of food · 2024Article
- Comparative Analysis of Biomarkers in Type 2 Diabetes Patients With and Without Comorbidities: Insights Into the Role of Hypertension and Cardiovascular Disease.Biomarker insights · 2024Article
- Comparative Effectiveness of Oral Hypoglycemic Agents for Glycemic Control and Glycemic Variability in Patients with Type 2 Diabetes Mellitus: Using Flash Glucose Monitoring.Current diabetes reviews · 2024Article
- Biomarkers of Oxidative Stress in Diabetes Mellitus with Diabetic Nephropathy Complications.International journal of molecular sciences · 2023Article
- Defining the nuanced nature of redox biology in post-traumatic stress disorder.Frontiers in physiology · 2023Review
- Elevated Urinary Biomarkers of Oxidative Damage in Photocopier Operators following Acute and Chronic Exposures.Nanomaterials (Basel, Switzerland) · 2022Article
- Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic risk in young adults.Obesity (Silver Spring, Md.) · 2022Article
- High Oxygen Does Not Increase Reperfusion Injury Assessed with Lipid Peroxidation Biomarkers after Cardiac Arrest: A Post Hoc Analysis of the COMACARE Trial.Journal of clinical medicine · 2021Article
- Curcumin reduces enteric isoprostane 8-iso-PGF2α and prostaglandin GF2α in specific pathogen-free Leghorn chickens challenged with Eimeria maxima.Scientific reports · 2021Article
- Contribution of Adipose Tissue Oxidative Stress to Obesity-Associated Diabetes Risk and Ethnic Differences: Focus on Women of African Ancestry.Antioxidants (Basel, Switzerland) · 2021Review
- Wolfberry (Antioxidants (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress (OS) has been implicated as one of the major underlying mechanisms behind many acute and chronic diseases. However, the measurement of free radicals or their end products is complicated. Isoprostanes, derived from the non-enzymatic peroxidation of arachidonic acid are now considered to be reliable biomarkers of oxidant stress in the human body. Isoprostanes are involved in many of the human diseases such as type 2 diabetes. In type 2 diabetes elevated levels of F(2)-Isoprostanes (F(2)-IsoPs) have been observed. The measurement of bioactive F(2)-IsoPs levels offers a unique noninvasive analytical tool to study the role of free radicals in physiology, oxidative stress-related diseases, and acute or chronic inflammatory conditions. Measurement of oxidative stress by various other methods lacks specificity and sensitivity. This review aims to shed light on the implemention of F(2)-IsoPs measurement as a gold-standard biomarker of oxidative stress in type 2 diabetics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.