ArticleEnvironmental health perspectives2009
Thyroid hormone levels of pregnant inuit women and their infants exposed to environmental contaminants.
Article in Environmental health perspectives, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- A decade of research in Inuit children, youth, and maternal health in Canada: areas of concentrations and scarcities.International journal of circumpolar health · 2012Pooled it
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- Maternal exposure to OEnvironmental science and pollution research international · 2021Article
- Dietary Intake of Endocrine Disrupting Substances Presents in Environment and Their Impact on Thyroid Function.Nutrients · 2021Review
- Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster.Scientific reports · 2020Article
- Human health risks due to airborne polychlorinated biphenyls are highest in New Bedford Harbor communities living closest to the harbor.The Science of the total environment · 2020Article
- Temporal trends of contaminants in Arctic human populations.Environmental science and pollution research international · 2018Review
- Thyroid-disrupting chemicals and brain development: an update.Endocrine connections · 2018Review
- Thyroid-stimulating hormone levels in newborns and early life exposure to endocrine-disrupting chemicals: analysis of three European mother-child cohorts.Pediatric research · 2017Article
- Hydroxylated polychlorinated biphenyl metabolites (OH-PCBs), maternal smoking and size at birth.Reproductive toxicology (Elmsford, N.Y.) · 2017Article
- Maternal body burdens of PCDD/Fs and PBDEs are associated with maternal serum levels of thyroid hormones in early pregnancy: a cross-sectional study.Environmental health : a global access science source · 2016Article
- A Preliminary Link between Hydroxylated Metabolites of Polychlorinated Biphenyls and Free Thyroxin in Humans.International journal of environmental research and public health · 2016Article
- Health effects associated with measured levels of contaminants in the Arctic.International journal of circumpolar health · 2016Article
- Metabolism and metabolites of polychlorinated biphenyls.Critical reviews in toxicology · 2015Review
- Cancer risks and long-term community-level exposure to pentachlorophenol in contaminated areas, China.Environmental science and pollution research international · 2015Article
- Prenatal exposure to endocrine disrupting chemicals in relation to thyroid hormone levels in infants - a Dutch prospective cohort study.Environmental health : a global access science source · 2014Article
- Occurrence and distribution of PCB metabolites in blood and their potential health effects in humans: a review.Environmental science and pollution research international · 2014Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundAn increasing number of studies have shown that several ubiquitous environmental contaminants possess thyroid hormone-disrupting capacities. Prenatal exposure to some of them, such as polychlorinated biphenyls (PCBs), has also been associated with adverse neurodevelopmental effects in infants.
objectivesIn this study we examined the relationship between exposure to potential thyroid hormone-disrupting toxicants and thyroid hormone status in pregnant Inuit women from Nunavik and their infants within the first year of life.
methodsWe measured thyroid hormone parameters [thyroid stimulating hormone (TSH), free thyroxine (fT(4)), total triiodothyronine (T(3)), thyroxine-binding globulin (TBG)] and concentrations of several contaminants [PCB-153, hydroxylated metabolites of PCBs (HO-PCBs), pentachlorophenol (PCP) and hexachlorobenzene (HCB)] in maternal plasma at delivery (n = 120), in umbilical cord plasma (n = 95), and in infant plasma at 7 months postpartum (n = 130).
resultsIn pregnant women, we found a positive association between HO-PCBs and T(3) concentrations (beta = 0.57, p = 0.02). In umbilical cord blood, PCB-153 concentrations were negatively associated with TBG levels (beta = -0.26, p = 0.01). In a subsample analysis, a negative relationship was also found between maternal PCP levels and cord fT(4) concentrations in neonates (beta = -0.59, p = 0.02). No association was observed between contaminants and thyroid hormones at 7 months of age.
conclusionOverall, there is little evidence that the environmental contaminants analyzed in this study affect thyroid hormone status in Inuit mothers and their infants. The possibility that PCP may decrease thyroxine levels in neonates requires further investigation.
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