ArticleEnvironmental health perspectives2009
Perturbation of defense pathways by low-dose arsenic exposure in zebrafish embryos.
Article in Environmental health perspectives, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
- Forward genetic screen in zebrafish identifies new fungal regulators that limit host-protectivemBio · 2025Article
- Integrated mRNA- and miRNA-sequencing analyses unveil the underlying mechanism of tobacco pollutant-induced developmental toxicity in zebrafish embryos.Journal of translational medicine · 2024Article
- Redundant Trojan horse and endothelial-circulatory mechanisms for host-mediated spread of Candida albicans yeast.PLoS pathogens · 2020Article
- Cross sectional association of arsenic and seroprevalence of hepatitis B infection in the United States (NHANES 2003-2014).Environmental research · 2018Article
- Arsenic Reduces Gene Expression Response to Changing Salinity in Killifish.Environmental science & technology · 2018Article
- Arsenic exposure and the seroprevalence of total hepatitis A antibodies in the US population: NHANES, 2003-2012.Epidemiology and infection · 2016Article
- Advancing toxicology research using in vivo high throughput toxicology with small fish models.ALTEX · 2016Article
- Metabolomic Characterizations of Liver Injury Caused by Acute Arsenic Toxicity in Zebrafish.PloS one · 2016Article
- Role ofBiochemistry and biophysics reports · 2015Article
- Zebrafish: A marvel of high-throughput biology for 21Current environmental health reports · 2014Article
- Arsenic immunotoxicity: a review.Environmental health : a global access science source · 2013Review
- Mucosal candidiasis elicits NF-κB activation, proinflammatory gene expression and localized neutrophilia in zebrafish.Disease models & mechanisms · 2013Article
- Differential DNA methylation in umbilical cord blood of infants exposed to low levels of arsenic in utero.Environmental health perspectives · 2013Article
- Systems biology and birth defects prevention: blockade of the glucocorticoid receptor prevents arsenic-induced birth defects.Environmental health perspectives · 2013Article
- Arsenic exposure to killifish during embryogenesis alters muscle development.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- Ranking transitive chemical-disease inferences using local network topology in the comparative toxicogenomics database.PloS one · 2012Article
- Aquatic models, genomics and chemical risk management.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2012Article
- Global gene expression analysis reveals dynamic and developmental stage-dependent enrichment of lead-induced neurological gene alterations.Environmental health perspectives · 2011Article
- Dose-responsive gene expression changes in juvenile and adult mummichogs (Fundulus heteroclitus) after arsenic exposure.Marine environmental research · 2010Article
- Arsenic inhibits SGK1 activation of CFTR Cl- channels in the gill of killifish, Fundulus heteroclitus.Aquatic toxicology (Amsterdam, Netherlands) · 2010Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundExposure to arsenic is a critical risk factor in the complex interplay among genetics, the environment, and human disease. Despite the potential for in utero exposure, the mechanism of arsenic action on vertebrate development and disease is unknown.
objectivesThe objective of this study was to identify genes and gene networks perturbed by arsenic during development in order to enhance understanding of the molecular mechanisms of arsenic action.
methodsWe exposed zebrafish embryos at 0.25-1.25 hr postfertilization to 10 or 100 ppb arsenic for 24 or 48 hr. We then used total RNA to interrogate genome microarrays and to test levels of gene expression changes by quantitative real-time polymerase chain reaction (QPCR). Computational analysis was used to identify gene expression networks perturbed by arsenic during vertebrate development.
resultsWe identified a set of 99 genes that responded to low levels of arsenic. Nineteen of these genes were predicted to function in a common regulatory network that was significantly associated with immune response and cancer (p < 10(-41)). Arsenic-mediated expression changes were validated by QPCR.
conclusionsIn this study we demonstrated that arsenic significantly down-regulates expression levels of multiple genes potentially critical for regulating the establishment of an immune response. The data also provide molecular evidence consistent with phenotypic observations reported in other model systems. Additional mechanistic studies will help explain molecular events regulating early stages of the immune system and long-term consequences of arsenic-mediated perturbation of this system during development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.