ArticleEnvironmental health perspectives2009
Increased expression of histone proteins during estrogen-mediated cell proliferation.
Article in Environmental health perspectives, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- A novel age-related gene expression signature associates with proliferation and disease progression in breast cancer.British journal of cancer · 2022Article
- The protein-protein interaction network of intestinal gastric cancer patients reveals hub proteins with potential prognostic value.Cancer biomarkers : section A of Disease markers · 2022Article
- Genome-Wide Analysis of Low Dose Bisphenol-A (BPA) Exposure in Human Prostate Cells.Current genomics · 2019Article
- Proteomic analysis of the effects of antler extract on chondrocyte proliferation, differentiation and apoptosis.Molecular biology reports · 2019Article
- Molecular changes during extended neoadjuvant letrozole treatment of breast cancer: distinguishing acquired resistance from dormant tumours.Breast cancer research : BCR · 2019Article
- BPA-Induced Deregulation Of Epigenetic Patterns: Effects On Female Zebrafish Reproduction.Scientific reports · 2016Article
- Current concepts in neuroendocrine disruption.General and comparative endocrinology · 2014Review
- Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.Circulation · 2012Article
- Epigenetic perspective on the developmental effects of bisphenol A.Brain, behavior, and immunity · 2011Review
- The role of Bisphenol A in shaping the brain, epigenome and behavior.Hormones and behavior · 2011Review
- Epigenomic disruption: the effects of early developmental exposures.Birth defects research. Part A, Clinical and molecular teratology · 2010Review
- Intratumoral heterogeneity of breast cancer xenograft models: texture analysis of diffusion-weighted MR imaging.Korean journal of radiologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is concern about the potential risk posed by compounds with estrogen-like activity present in the environment. As previous studies have shown that combined exposure to such compounds results in dose additivity, it should be possible to assess estrogen exposure with suitable biomarkers of effect.
objectivesOur goal was to identify candidate protein biomarkers of effect for estrogenic compounds.
methodsIn the search for biomarkers, we assessed the effect of several estrogenic compounds on the expression profile of proteins in breast-derived cell lines varying in their estrogen receptor (ER) phenotype using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. We identified responsive proteins, after separating them by SDS-polyacrylamide gel electrophoresis, and analyzing the trypsin-digested proteins by tandem mass spectrometry.
resultsThe estrogenic compounds 17beta-estradiol, genistein, bisphenol A, and endosulfan produced similar protein profile changes in MCF-7 cells (phenotype: ERalpha(+)/ERbeta(+)), but had no effect on MDA-MB-231 (ERalpha(-)/ERbeta(+)), MCF-10F (ERalpha(-)/ERbeta(+)), or MCF-10A (ERalpha(-)/ERbeta(-)) cells. The most responsive proteins in MCF-7 cells were identified as histones H2A, H2B, H3, and H4. Histone levels were not increased in cell lines that showed no proliferative response to estrogens despite their rapid intrinsic growth rate in culture.
conclusionOur results indicate that ER-mediated cell proliferation results in up-regulation of core histone proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.