ArticleThe Journal of trauma2009
Pulmonary contusion primes systemic innate immunity responses.
Article in The Journal of trauma, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Attenuating pulmonary injury and inflammation with C5/CD14 inhibition therapy: results from a porcine polytrauma model with blunt chest trauma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Impact of the Early Use of High-flow Nasal Cannula in Patients with Post-traumatic Lung Contusion: A Randomized Clinical Trial.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Lung contusion complicated by pneumonia worsens lung injury via the inflammatory effect of alveolar small extracellular vesicles on macrophages and epithelial cells.The journal of trauma and acute care surgery · 2025Article
- Understanding the role of neutrophils in acute respiratory distress syndrome.Biomedical journal · 2021Review
- Contributing factors in the development of acute lung injury in a murine double hit model.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Article
- The Effects of Dexmedetomidine and Ketamine on Oxidative Injuries and Histological Changes Following Blunt Chest Trauma.Drug design, development and therapy · 2020Article
- Endogenous Uteroglobin as Intrinsic Anti-inflammatory Signal Modulates Monocyte and Macrophage Subsets Distribution Upon Sepsis Induced Lung Injury.Frontiers in immunology · 2019Article
- The effect of aerosolized indomethacin on lung inflammation and injury in a rat model of blunt chest traumaCanadian journal of surgery. Journal canadien de chirurgie · 2018Article
- A Study of the Therapeutic Effects of Resveratrol on Blunt Chest Trauma-Induced Acute Lung Injury in Rats and the Potential Role of Endocan as a Biomarker of Inflammation.Inflammation · 2017Article
- The multistep road to ventilator-associated lung abscess: A retrospective study of S.aureus ventilator-associated pneumonia.PloS one · 2017Article
- SIRT1 mediates a primed response to immune challenge after traumatic lung injury.The journal of trauma and acute care surgery · 2015Article
- Substance P mediates reduced pneumonia rates after traumatic brain injury.Critical care medicine · 2014Article
- Interleukin 10 overexpression alters survival in the setting of gram-negative pneumonia following lung contusion.Shock (Augusta, Ga.) · 2014Article
- Complement mediates a primed inflammatory response after traumatic lung injury.The journal of trauma and acute care surgery · 2014Article
- Pulmonary contusion is associated with toll-like receptor 4 upregulation and decreased susceptibility to pseudomonas pneumonia in a mouse model.Shock (Augusta, Ga.) · 2012Article
- Innate immune response to pulmonary contusion: identification of cell type-specific inflammatory responses.Shock (Augusta, Ga.) · 2012Article
- Isolated blunt chest injury leads to transient activation of circulating neutrophils.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2011Article
- Expression patterns of plasma von Willebrand factor and serum interleukin-8 in patients with early-stage severe pulmonary contusion.World journal of emergency medicine · 2011Article
- Dexmedetomidine versus ketamine in improving tolerance to noninvasive ventilation after blunt chest trauma: A randomized, double-blinded, placebo-controlled trial.Journal of anaesthesiology, clinical pharmacologyArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionTraumatic injury may result in an exaggerated response to subsequent immune stimuli such as nosocomial infection. This "second hit" phenomenon and molecular mechanism(s) of immune priming by traumatic lung injury, specifically, pulmonary contusion, remain unknown. We used an animal model of pulmonary contusion to determine whether the injury resulted in priming of the innate immune response and to test the hypothesis that resuscitation fluids could attenuate the primed response to a second hit.
methodsMale, 8 to 9 weeks, C57/BL6 mice with a pulmonary contusion were challenged by a second hit of intratracheal administration of the Toll-like receptor 4 agonist, lipopolysaccharide (LPS, 50 microg) 24 hours after injury (injury + LPS). Other experimental groups were injury + vehicle or LPS alone. A separate group was injured and resuscitated by 4 cc/kg of hypertonic saline (HTS) or Lactated Ringer's (LR) resuscitation before LPS challenge. Mice were killed 4 hours after LPS challenge and blood, bronchoalveolar lavage, and tissue were isolated and analyzed. Data were analyzed using one-way analysis of variance with Bonferroni multiple comparison posttest for significant differences (*p < or = 0.05).
resultsInjury + LPS showed immune priming observed by lung injury histology and increased bronchoalveolar lavage neutrophilia, lung myeloperoxidase and serum IL-6, CXCL1, and MIP-2 levels when compared with injury + vehicle or LPS alone. After injury, resuscitation with HTS, but not Lactated Ringer's was more effective in attenuating the primed response to a second hit.
conclusionPulmonary contusion primes innate immunity for an exaggerated response to a second hit with the Toll-like receptor 4 agonist, LPS. We observed synergistic increases in inflammatory mediator expression in the blood and a more severe lung injury in injured animals challenged with LPS. This priming effect was reduced when HTS was used to resuscitate the animal after lung contusion.
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