ArticleMolecular biology and evolution2009
Rapid sequence evolution of transcription factors controlling neuron differentiation in Caenorhabditis.
Article in Molecular biology and evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Patterns of Genomic Diversity in a Fig-Associated Close Relative of Caenorhabditis elegans.Genome biology and evolution · 2024Article
- Mechanisms of transcription factor evolution in Metazoa.Nucleic acids research · 2016Article
- Comparative genomic analysis of upstream miRNA regulatory motifs in Caenorhabditis.RNA (New York, N.Y.) · 2016Article
- Molecular Evolution of Drosophila Germline Stem Cell and Neural Stem Cell Regulating Genes.Genome biology and evolution · 2015Article
- Hybrid incompatibility arises in a sequence-based bioenergetic model of transcription factor binding.Genetics · 2014Article
- Microevolution of nematode miRNAs reveals diverse modes of selection.Genome biology and evolution · 2014Article
- Modular evolution of DNA-binding preference of a Tbrain transcription factor provides a mechanism for modifying gene regulatory networks.Molecular biology and evolution · 2014Article
- A recent global selective sweep on the age-1 phosphatidylinositol 3-OH kinase regulator of the insulin-like signaling pathway within Caenorhabditis remanei.G3 (Bethesda, Md.) · 2014Article
- Molecular hyperdiversity defines populations of the nematode Caenorhabditis brenneri.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Molecular hyperdiversity and evolution in very large populations.Molecular ecology · 2013Article
- Global population genetic structure of Caenorhabditis remanei reveals incipient speciation.Genetics · 2012Article
- MicroRNA sequence variation potentially contributes to within-species functional divergence in the nematode Caenorhabditis briggsae.Genetics · 2011Article
- Expression level drives the pattern of selective constraints along the insulin/Tor signal transduction pathway in Caenorhabditis.Genome biology and evolution · 2011Article
- Selection at linked sites shapes heritable phenotypic variation in C. elegans.Science (New York, N.Y.) · 2010Article
- The homeodomain protein hmbx-1 maintains asymmetric gene expression in adult C. elegans olfactory neurons.Genes & development · 2010Article
- Cis-regulatory mechanisms of gene expression in an olfactory neuron type in Caenorhabditis elegans.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
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1 author at 1 institution in 1 country.
Funding
Abstract
Whether phenotypic evolution proceeds predominantly through changes in regulatory sequences is a controversial issue in evolutionary genetics. Ample evidence indicates that the evolution of gene regulatory networks via changes in cis-regulatory sequences is an important determinant of phenotypic diversity. However, recent experimental work suggests that the role of transcription factor (TF) divergence in developmental evolution may be underestimated. In order to help understand what levels of constraints are acting on the coding sequence of developmental regulatory genes, evolutionary rates were investigated among 48 TFs required for neuronal development in Caenorhabditis elegans. Allelic variation was then sampled for 28 of these genes within a population of the related species Caenorhabditis remanei. Neuronal TFs are more divergent, both within and between species, than structural genes. TFs affecting different neuronal classes are under different levels of selective constraints. The regulatory genes controlling the differentiation of chemosensory neurons evolve particularly fast and exhibit higher levels of within- and between-species nucleotide variation than TFs required for the development of several neuronal classes and TFs required for motorneuron differentiation. The TFs affecting chemosensory neuron development are also more divergent than chemosensory genes expressed in the neurons they differentiate. These results illustrate that TFs are not as highly constrained as commonly thought and suggest that the role of divergence in developmental regulatory genes during the evolution of gene regulatory networks requires further attention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.