ArticleThe Journal of biological chemistry2009
Nuclear export-independent inhibition of Foxa2 by insulin.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Reversion of passaged nucleus pulposus cells to notochordal-type cells by FoxA2 upregulation.NPJ Regenerative medicine · 2025Article
- Ginger nanoparticles mediated induction of Foxa2 prevents high-fat diet-induced insulin resistance.Theranostics · 2022Article
- Selinexor and the Selective Inhibition of Nuclear Export: A New Perspective on the Treatment of Sarcomas and Other Solid and Non-Solid Tumors.Pharmaceutics · 2021Review
- Inactivation of FOXA2 by Respiratory Bacterial Pathogens and Dysregulation of Pulmonary Mucus Homeostasis.Frontiers in immunology · 2020Review
- Down-regulation of aquaporin 9 gene transcription by 10-hydroxy-2-decenoic acid: A major fatty acid in royal jelly.Food science & nutrition · 2019Article
- The reduction in FOXA2 activity during lung development in fetuses from diabetic rat mothers is reversed by Akt inhibition.FEBS open bio · 2018Article
- Article
- Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells.Genome medicine · 2017Article
- Role of transcription factor acetylation in the regulation of metabolic homeostasis.Protein & cell · 2015Review
- Pregnane X Receptor Represses HNF4α Gene to Induce Insulin-Like Growth Factor-Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells.Molecular pharmacology · 2015Article
- Review
- Article
- Reverse causal reasoning: applying qualitative causal knowledge to the interpretation of high-throughput data.BMC bioinformatics · 2013Article
- Forkhead box A1 (FOXA1) is a key mediator of insulin-like growth factor I (IGF-I) activity.Journal of cellular biochemistry · 2012Article
- Foxa1 reduces lipid accumulation in human hepatocytes and is down-regulated in nonalcoholic fatty liver.PloS one · 2012Article
- Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport.Nature medicine · 2011Article
- Stable chromatin binding prevents FoxA acetylation, preserving FoxA chromatin remodeling.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Forkhead box A2 transcription factor (Foxa2/HNF-3beta) has been shown to be a key regulator of genes involved in the maintenance of glucose and lipid homeostasis in the liver. It is constitutively inactivated in several hyperinsulinemic/obese mouse models, thereby enhancing their metabolic phenotypes. Foxa2 is activated under fasting conditions but is inhibited by insulin signaling via phosphatidylinositol 3-kinase/AKT in a phosphorylation-dependent manner, which results in its nuclear exclusion. However, the mechanism and relative importance of its nuclear export has not yet been elucidated. Here we show that Foxa2 contains a functional nuclear export signal and is excluded from the nucleus via a CRM1-dependent pathway in response to insulin signaling. Furthermore, direct evidence is provided that nuclear export-defective Foxa2 is phosphorylated and inactivated by insulin in vitro and in vivo. These data demonstrate for the first time that phosphorylation itself is the main event regulating the activity of Foxa2, suggesting that export-independent mechanisms have evolved to ensure inhibition of Foxa2 under conditions in which insulin signaling is present.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.