ArticleAutonomic neuroscience : basic & clinical2009
Inhibition of RVLM synaptic activation at peak hyperthermia reduces visceral sympathetic nerve discharge.
Article in Autonomic neuroscience : basic & clinical, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Does acute heat stress differentially-modulate expression of ionotropic neurotransmitter receptors in the RVLM of young and aged F344 rats?Neuroscience letters · 2018Article
- Effect of ghrelin on regulation of splenic sympathetic nerve discharge.Autonomic neuroscience : basic & clinical · 2016Article
- Medullary regulation of visceral sympathetic nerve discharge at peak hyperthermia in aged F344 rats.Autonomic neuroscience : basic & clinical · 2014Article
- Dexmedetomidine and regulation of splenic sympathetic nerve discharge.Autonomic neuroscience : basic & clinical · 2014Article
- Autonomic nervous system and immune system interactions.Comprehensive Physiology · 2014Review
- Disinhibition of RVLM neural circuits and regulation of sympathetic nerve discharge at peak hyperthermia.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Bacillus anthracis lethal toxin induces complex changes in sympathetic nerve discharge regulation.Autonomic neuroscience : basic & clinical · 2012Article
- Bacillus anthracis lethal toxin alters regulation of visceral sympathetic nerve discharge.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Is visceral sympathoexcitation to heat stress dependent on activation of ionotropic excitatory amino acid receptors in the rostral ventrolateral medulla?American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Effects of combined aging and heart failure on visceral sympathetic nerve and cardiovascular responses to progressive hyperthermia in F344 rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Animal aging and regulation of sympathetic nerve discharge.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hyperthermia is an environmental stressor that produces marked increases in visceral sympathetic nerve discharge (SND) in young rats. The brainstem in rats contains the essential neural circuitry for mediating visceral sympathetic activation; however, specific brainstem sites involved remain virtually unknown. The rostral ventral lateral medulla (RVLM) is a key central nervous system region involved in the maintenance of basal SND and in mediating sympathetic nerve responses evoked from supraspinal sites. In the present study we tested the hypothesis that inhibition of RVLM synaptic activation at peak hyperthermia (internal body temperature, Tc, increased to 41.5 degrees C) would affect heating-induced visceral sympathetic activation. Experiments were completed in chloralose-urethane anesthetized, baroreceptor-intact and sinoaortic-denervated, 3-6 month-old Sprague-Dawley rats. Bilateral inhibition of RVLM synaptic activation produced by muscimol microinjections (400 and 800 pmol) at 41.5 degrees C resulted in immediate and significant reductions in peak heating-induced renal and splenic sympathoexcitation. Interruption of RVLM synaptic activation and axonal transmission by lidocaine microinjections (40 nmol) at 41.5 degrees C produced significant reductions in hyperthermia-induced sympathetic activation to similar levels produced by RVLM muscimol microinjections. The total amount of SND inhibited by RVLM muscimol and lidocaine microinjections was significantly more during hyperthermia (41.5 degrees C) than normothermia (38 degrees C). These findings demonstrate that maintenance of sympathetic activation at peak hyperthermia is dependent on the integrity of RVLM neural circuits.
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