ReviewCurrent HIV/AIDS reports2009
Management of patients with the immune reconstitution inflammatory syndrome.
Review in Current HIV/AIDS reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 66 citations in OpenAlex.
- Matrix metalloproteinases and tissue damage in HIV-tuberculosis immune reconstitution inflammatory syndrome.European journal of immunology · 2014Trial
- Case Report and Literature Review of "Treatment Failure" of Aspergillus Infection Secondary to Influenza a Virus.Journal of inflammation research · 2024Article
- Tuberculosis IRIS: Pathogenesis, Presentation, and Management across the Spectrum of Disease.Life (Basel, Switzerland) · 2020Review
- Miliary Tuberculosis.Microbiology spectrum · 2017Review
- Immune reconstitution inflammatory syndrome associated with pulmonary pathogens.European respiratory review : an official journal of the European Respiratory Society · 2017Review
- Natalizumab-Related Progressive Multifocal Leukoencephalopathy-Immune Reconstitution Inflammatory Syndrome: A Case Report Highlighting Clinical and MRI Features.The Malaysian journal of medical sciences : MJMS · 2016Article
- Crucial Role of Viral Reactivation in the Development of Severe Drug Eruptions: a Comprehensive Review.Clinical reviews in allergy & immunology · 2015Review
- Host-Directed Therapies for Tuberculosis.Cold Spring Harbor perspectives in medicine · 2015Review
- Immune reconstitution inflammatory syndrome in HIV-infected patients.HIV/AIDS (Auckland, N.Z.) · 2015Review
- Acute renal injury in a 14-year-old with HIV/AIDS and tuberculosis.The Pediatric infectious disease journal · 2013Article
- Immune restoration after antiretroviral therapy: the pitfalls of hasty or incomplete repairs.Immunological reviews · 2013Review
- HIV-1 and the immune response to TB.Future virology · 2013Article
- Large liquefaction of lymph nodes during tuberculosis-associated immune reconstitution inflammatory syndrome in an HIV-infected woman.BMJ case reports · 2012Article
- Management of the immune reconstitution inflammatory syndrome.Current HIV/AIDS reports · 2012Review
- Challenges in the diagnosis & treatment of miliary tuberculosis.The Indian journal of medical research · 2012Review
- Hypercytokinaemia accompanies HIV-tuberculosis immune reconstitution inflammatory syndrome.The European respiratory journal · 2011Article
- Pathogenesis and prevention of immune reconstitution disease during antiretroviral therapy.Expert review of anti-infective therapy · 2011Review
- HIV and tuberculosis: a deadly human syndemic.Clinical microbiology reviews · 2011Review
- Antiretroviral treatment 2010: progress and controversies.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- Central nervous system disorders after starting antiretroviral therapy in South Africa.AIDS (London, England) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A significant proportion of patients present with the immune reconstitution inflammatory syndrome (IRIS) after commencing antiretroviral therapy (ART). This syndrome is most frequently associated with infective causes. The lack of evidence-based treatment guidelines poses challenges in the management of these patients. Alternative causes for deterioration should be excluded, and optimization of treatment for the underlying opportunistic infection is essential. In addition, anti-inflammatory or immunomodulatory therapy may be considered, particularly in severe cases. Corticosteroids, the only treatment for which clinical trial data exist (for treating paradoxical tuberculosis-associated IRIS), are the treatment most frequently used in IRIS. Limited anecdotal reports of benefit exist for other agents, including NSAIDs, pentoxifylline, montelukast, thalidomide, and hydroxychloroquine. Therapeutic procedures (eg, aspiration of pus collections) play an important role in some patients. Interruption of ART may be considered in life-threatening forms of IRIS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.