ArticleMalaria journal2009
Glucose-6-phosphate dehydrogenase (G6PD) mutations and haemoglobinuria syndrome in the Vietnamese population.
Article in Malaria journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- A Randomized Comparison of Chloroquine Versus Dihydroartemisinin-Piperaquine for the Treatment of Plasmodium vivax Infection in Vietnam.The American journal of tropical medicine and hygiene · 2016Trial
- Confirmed Plasmodium vivax Resistance to Chloroquine in Central Vietnam.Antimicrobial agents and chemotherapy · 2015Trial
- Prevalence of common autosomal recessive mutation carriers in women in the Southern Vietnam following the application of expanded carrier screening.Scientific reports · 2024Article
- Blackwater fever and acute kidney injury in children hospitalized with an acute febrile illness: pathophysiology and prognostic significance.BMC medicine · 2022Observational
- Massively parallel sequencing uncovered disease-associated variant spectra of glucose-6-phosphate dehydrogenase deficiency, phenylketonuria and galactosemia in Vietnamese pregnant women.Molecular genetics & genomic medicine · 2022Article
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- Distribution of G6PD deficiency genotypes among Southeast Asian populations.Tropical medicine and health · 2021Review
- Genotype-Phenotype Correlation of G6PD Mutations among Central Thai Children with G6PD Deficiency.Anemia · 2021Article
- Molecular Characterization of G6PD Deficiency at a North Indian Centre: Implications for Diagnostic Testing Laboratories in Different Regions of India.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2020Article
- G6PD genetic variations in neonatal Hyperbilirubinemia in Indonesian Deutromalay population.BMC pediatrics · 2019Article
- Clinical impact of the two ART resistance markers, K13 gene mutations and DPC3 in Vietnam.PloS one · 2019Article
- A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether-lumefantrine treatment.Malaria journal · 2018Article
- Systematic review of the clinical manifestations of glucose-6-phosphate dehydrogenase deficiency in the Greater Mekong Subregion: implications for malaria elimination and beyond.BMJ global health · 2017Article
- Glucose-6-Phosphate Dehydrogenase: Update and Analysis of New Mutations around the World.International journal of molecular sciences · 2016Review
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- Characterization of G6PD genotypes and phenotypes on the northwestern Thailand-Myanmar border.PloS one · 2014Article
- CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever.Malaria journal · 2013Article
- Haemoglobin dynamics in Papuan and non-Papuan adults in northeast Papua, Indonesia, with acute, uncomplicated vivax or falciparum malaria.Malaria journal · 2013Article
- Prevalence of G6PD Deficiency in Iran.International journal of hematology-oncology and stem cell research · 2013Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundIn Vietnam the blackwater fever syndrome (BWF) has been associated with malaria infection, quinine ingestion and G6PD deficiency. The G6PD variants within the Vietnamese Kinh contributing to the disease risk in this population, and more generally to haemoglobinuria, are currently unknown.
methodEighty-two haemoglobinuria patients and 524 healthy controls were screened for G6PD deficiency using either the methylene blue reduction test, the G-6-PDH kit or the micro-methaemoglobin reduction test. The G6PD gene variants were screened using SSCP combined with DNA sequencing in 82 patients with haemoglobinuria, and in 59 healthy controls found to be G6PD deficient.
resultsThis study confirmed that G6PD deficiency is strongly associated with haemoglobinuria (OR = 15, 95% CI [7.7 to 28.9], P < 0.0001). Six G6PD variants were identified in the Vietnamese population, of which two are novel (Vietnam1 [Glu3Lys] and Vietnam2 [Phe66Cys]). G6PD Viangchan [Val291Met], common throughout south-east Asia, accounted for 77% of the variants detected and was significantly associated with haemoglobinuria within G6PD-deficient ethnic Kinh Vietnamese (OR = 5.8 95% CI [114-55.4], P = 0.022).
conclusionThe primary frequency of several G6PD mutations, including novel mutations, in the Vietnamese Kinh population are reported and the contribution of G6PD mutations to the development of haemoglobinuria are investigated.
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