ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2009
contribution of genetically restricted, methicillin-susceptible strains to the ongoing epidemic of community-acquired Staphylococcus aureus infections.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 57 citations in OpenAlex.
- Household versus individual approaches to eradication of community-associated Staphylococcus aureus in children: a randomized trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Trial
- Effectiveness of measures to eradicate Staphylococcus aureus carriage in patients with community-associated skin and soft-tissue infections: a randomized trial.Infection control and hospital epidemiology · 2011Trial
- Management and Prevention of Staphylococcus aureus Infections in Children.Infectious disease clinics of North America · 2022Review
- A Longitudinal Study of Adult Patients withJournal of Korean medical science · 2021Article
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- Human Infection of Methicillin-SusceptibleMicroorganisms · 2020Review
- Methicillin-Resistant Staphylococcus aureus Eradication and Decolonization in Children Study (Part 1): Development of a Decolonization Toolkit With Patient and Parent Advisors.Journal of participatory medicine · 2020Article
- Methicillin-Resistant Staphylococcus aureus Eradication and Decolonization in Children Study (Part 2): Patient- and Parent-Centered Outcomes of Decolonization.Journal of participatory medicine · 2020Article
- Article
- Prevention Strategies for Recurrent Community-Associated Staphylococcus aureus Skin and Soft Tissue Infections.Current infectious disease reports · 2019Review
- Article
- Prevention of Recurrent Staphylococcal Skin Infections.Infectious disease clinics of North America · 2015Review
- Discriminatory Indices of Typing Methods for Epidemiologic Analysis of Contemporary Staphylococcus aureus Strains.Medicine · 2015Article
- Human Infections with Staphylococcus aureus CC398.Current environmental health reports · 2015Review
- Livestock-associated Staphylococcus aureus: the United States experience.PLoS pathogens · 2015Review
- Staphylococcus aureus bacteremia at 5 US academic medical centers, 2008-2011: significant geographic variation in community-onset infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Article
- Clinical and molecular epidemiology of community-onset invasive Staphylococcus aureus infection in New Zealand children.Epidemiology and infection · 2014Article
- Will there ever be a universal Staphylococcus aureus vaccine?Human vaccines & immunotherapeutics · 2013Article
- Emergence of sequence type 398 as a community- and healthcare-associated methicillin-susceptible staphylococcus aureus in northern Manhattan.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- A serologic correlate of protective immunity against community-onset Staphylococcus aureus infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWithin the current worldwide epidemic of community-acquired Staphylococcus aureus infections, attention has focused on the role of methicillin-resistant strains. We characterize methicillin-susceptible strains that also contribute to this epidemic.
methodsWe tracked cultures from abscess specimens submitted to the microbiology laboratory at St. Louis Children's Hospital and examined Panton-Valentine leukocidin (PVL) genes in methicillin-susceptible S. aureus (MSSA) isolates. We further characterized some isolates by multilocus sequence typing, pulsed-field gel electrophoresis, antibiotic susceptibility, accessory gene regulator (agr) allele, and presence of the arcA gene of the arginine catabolic mobile element.
resultsFrom 1999 to 2007, we detected a 250-fold increase in cultures of abscesses yielding methicillin-resistant S. aureus (MRSA) and a 5-fold increase in abscess cultures yielding MSSA. MSSA isolates from abscesses and wounds were more likely to encode PVL than isolates from other sources. In contrast to PVL-negative isolates of MSSA, which were genetically diverse, PVL-positive isolates were predominantly multilocus sequence typing type 8 and agr type 1. More than half of PVL-positive MSSA isolates were resistant to erythromycin and susceptible to clindamycin with the absence of inducible resistance, a pattern uncommon in PVL-negative MSSA but frequent in the USA300 clone of MRSA. In addition, pulsed-field gel electrophoresis of PVL-positive MSSA strains revealed the USA300 pattern.
conclusionsIn addition to methicillin-resistant strains, the current epidemic of S. aureus infections includes infections caused by methicillin-susceptible strains that are closely related genetically and share phenotypic characteristics other than susceptibility to methicillin. These findings suggest that factors other than methicillin resistance are driving the epidemic.
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