SynthesisThe Cochrane database of systematic reviews2009
Danazol for uterine fibroids.
Synthesis in The Cochrane database of systematic reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Selective progesterone receptor modulators (SPRMs) for uterine fibroids.The Cochrane database of systematic reviews · 2017Pooled it
- Aromatase inhibitors for uterine fibroids.The Cochrane database of systematic reviews · 2013Pooled it
- Tailoring the Diagnostic Pathway for Medical and Surgical Treatment of Uterine Fibroids: A Narrative Review.Diagnostics (Basel, Switzerland) · 2024Review
- Androgen Signaling in Uterine Diseases: New Insights and New Targets.Biomolecules · 2022Review
- PLP1 may serve as a potential diagnostic biomarker of uterine fibroids.Frontiers in genetics · 2022Article
- Circulating Sex Hormones and Risk of Uterine Fibroids: Study of Women's Health Across the Nation (SWAN).The Journal of clinical endocrinology and metabolism · 2016Article
- Clinical utility of ulipristal acetate for the treatment of uterine fibroids: current evidence.International journal of women's health · 2015Review
- The conservative and interventional treatment of fibroids.Deutsches Arzteblatt international · 2014Review
- Pharmacological treatment of uterine fibroids.Annals of medical and health sciences research · 2014Review
- Ulipristal acetate: a novel pharmacological approach for the treatment of uterine fibroids.Drug design, development and therapy · 2014Review
- Medical treatment of uterine leiomyoma.Reproductive sciences (Thousand Oaks, Calif.) · 2012Review
- Innovative oral treatments of uterine leiomyoma.Obstetrics and gynecology international · 2012Article
- Current and emerging treatments for uterine myoma - an update.International journal of women's health · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUterine fibroids (myomas, fibromyomas, leiomyomas) are the most common benign tumours of the female genital tract. Danazol, a synthetic isoxazole derivative chemically related to 17-ethinyl testosterone, has been used for many years for the treatment of women with uterine fibroids.
objectivesTo evaluate the effectiveness and safety of danazol in women with uterine fibroids. SEARCH STRATEGY: We searched the Cochrane Menstrual Disorders and Subfertility Review Group Specialised Register; Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2008, Issue 4); MEDLINE; EMBASE; Chinese Biomedical Disc; and the China National Knowledge Infrastructure for relevant trials (to December 2008). Attempts were made to identify trials from references in published studies. We also searched for ongoing trials in the five major clinical trials registries. SELECTION CRITERIA: Randomised controlled trials of danazol versus placebo or any other medical therapy in women with uterine fibroids confirmed by medical procedures, regardless of the women's symptoms or age. Women with malignancies were excluded. DATA COLLECTION AND ANALYSIS: Data extraction and risk of bias assessment were not been performed because there were no identified studies. MAIN
resultsWe did not identify any studies which met our full inclusion criteria. AUTHORS'
conclusionsThere is no reliable evidence available from randomised controlled trials regarding the benefits and or harms of the use of danazol for treating uterine fibroids.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.