SynthesisThe Cochrane database of systematic reviews2009
Non-steroidal anti-inflammatory drugs for the common cold.
Synthesis in The Cochrane database of systematic reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Non-steroidal anti-inflammatory drugs for the common cold.The Cochrane database of systematic reviews · 2015Pooled it
- Acetaminophen (paracetamol) for the common cold in adults.The Cochrane database of systematic reviews · 2013Pooled it
- Efficacy of a carrageenan nasal spray in patients with common cold: a randomized controlled trial.Respiratory research · 2013Trial
- Efficacy of anti-inflammatory or antibiotic treatment in patients with non-complicated acute bronchitis and discoloured sputum: randomised placebo controlled trial.BMJ (Clinical research ed.) · 2013Trial
- Treatment of signs and symptoms of the common cold using EPs 7630 - results of a meta-analysis.Heliyon · 2019Review
- Non-steroidal Anti-inflammatory Drugs (NSAIDs) Use in Primary Health Care Centers in A'Seeb, Muscat: A Clinical Audit.Oman medical journal · 2015Article
- Public health and budget impact of probiotics on common respiratory tract infections: a modelling study.PloS one · 2015Article
- Evaluation of the prescriptions written for upper respiratory tract infections.Northern clinics of Istanbul · 2015Article
- Patient presentation and physician management of upper respiratory tract infections: a retrospective review of over 5 million primary clinic consultations in Hong Kong.BMC family practice · 2014Article
- Prevention and treatment of the common cold: making sense of the evidence.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014Review
- A crossover randomized comparative study of zofenopril and ramipril on cough reflex and airway inflammation in healthy volunteers.Cough (London, England) · 2014Article
- A Comparison of the Efficacy and Safety of Non-Steroidal Anti-Inflammatory Drugs versus Acetaminophen in Symptom Relief for the Common Cold: A Meta-Analysis of Randomized Controlled Trial Studies.Korean journal of family medicine · 2013Article
- Complementary and integrative treatments: upper respiratory infection.Otolaryngologic clinics of North America · 2013Review
- Treating cough and cold: Guidance for caregivers of children and youth.Paediatrics & child health · 2011Article
- Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole.Fluids and barriers of the CNS · 2011Article
- Complementary and alternative medicine for prevention and treatment of the common cold.Canadian family physician Medecin de famille canadien · 2011Review
- Reducing uncertainty in managing respiratory tract infections in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2010Article
Corrections and comments
- Updated by
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough non-steroidal anti-inflammatory drugs (NSAIDs) have been widely used for the treatment of pain and fever associated with the common cold, there is no systematic review to assess the effects of NSAIDs in patients with the common cold.
objectivesTo determine the effects of NSAIDs versus placebo and other treatments on the signs and symptoms of the common cold. To determine any adverse effects of NSAIDs in patients treated with NSAIDs for the common cold. SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2009, issue 1) which includes the Acute Respiratory Infections (ARI) Group's Specialized Register; MEDLINE (January 1966 to March 2009); EMBASE (January 1980 to March 2009); CINAHL (January 1982 to March 2009); ProQuest Digital Dissertations (January 1938 to March 2009); KoreaMed (January 1958 to March 2009) and KMbase (January 1949 to March 2009). SELECTION CRITERIA: Randomized controlled trials (RCTs) studying treatment of the common cold with NSAIDs in adults or children. DATA COLLECTION AND ANALYSIS: Four review authors extracted data (SYK, YSM, YJC, YWH). We subdivided trials into placebo-controlled RCTs and NSAIDs versus NSAIDs RCTs. We extracted and summarized data on global efficacies: analgesic effects such as reduction of headache and myalgia; non-analgesic effects such as reduction of nasal symptoms, cough, sputum and sneezing; and side effects. MAIN
resultsThis review includes nine RCTs, describing 37 comparisons: six were NSAIDs versus placebo, and three were NSAIDs versus NSAIDs. A total of 1064 patients with the common cold were included. In a pooled analysis, NSAIDs did not significantly reduce the total symptom score, or duration of colds.However, for outcomes related to the analgesic effects of NSAIDs (headache, ear pain, and muscle and joint pain) NSAIDs produced significant benefits, and malaise showed a borderline benefit, although throat irritation was not improved. Chills showed mixed results. For respiratory symptoms, cough and nasal discharge scores were not improved, but the sneezing score significantly improved. We found no evidence of increased frequency of adverse effects in the NSAID treatment groups. AUTHORS'
conclusionsThe authors recommend NSAIDs for relieving discomfort or pain caused by the common cold. Further research is needed to investigate the effect of NSAIDs in relieving respiratory symptoms such as cough and nasal discharge.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.