ArticleDigestive diseases and sciences2010
Soluble dietary fiber protects against nonsteroidal anti-inflammatory drug-induced damage to the small intestine in cats.
Article in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Rational use of gastroprotectants in cats: An evidence-based approach.Journal of feline medicine and surgery · 2024Review
- Role of omega-3 polyunsaturated fatty acids, citrus pectin, and milk-derived exosomes on intestinal barrier integrity and immunity in animals.Journal of animal science and biotechnology · 2022Review
- Intersecting Mechanisms of Hypoxia and Prostaglandin E2-Mediated Inflammation in the Comparative Biology of Oral Squamous Cell Carcinoma.Frontiers in oncology · 2021Review
- Gut Microbiota in NSAID Enteropathy: New Insights From Inside.Frontiers in cellular and infection microbiology · 2021Review
- Antiulcer and hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin-ulcerated rats.Biomedical journal · 2018Article
- Soluble Dietary Fiber Can Protect the Gastrointestinal Mucosa Against Nonsteroidal Anti-Inflammatory Drugs in Mice.Digestive diseases and sciences · 2016Article
- Soluble Dietary Fibers Can Protect the Small Intestinal Mucosa Without Affecting the Anti-inflammatory Effect of Indomethacin in Adjuvant-Induced Arthritis Rats.Digestive diseases and sciences · 2016Article
- Study of the protective effect on intestinal mucosa of the hydrosoluble fiber Plantago ovata husk.BMC complementary and alternative medicine · 2015Article
- The role of food for the formation and prevention of gastrointestinal lesions induced by aspirin in cats.Digestive diseases and sciences · 2013Article
- Wireless capsule endoscopy in enteropathy induced by nonsteroidal anti-inflammatory drugs in pigs.Digestive diseases and sciences · 2010Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNonsteroidal anti-inflammatory drugs (NSAIDs) often cause ulcers in the small intestine in humans, but there are few effective agents for treatment of small intestinal ulcers. We found that soluble dietary fibers (SDFs), such as pectin, could prevent the formation of small intestinal lesions induced by indomethacin (IND) in cats. To elucidate the mechanism of protection by SDFs, we examined the viscosities of SDFs and the effects of pectin on gastrointestinal absorption of IND and intestinal hypermotility induced by IND.
methodsCats were given regular dry food (RFD-Dry) or RFD-Dry supplemented with pectin, guar gum, polydextrose, or mucin twice daily. IND was administered orally once daily for 3 days. Mucosal lesions in the small intestine were examined 24 h after the final dosing of IND. Plasma concentrations of IND were measured by HPLC. GI motilities were measured using a telemetry system in conscious cats implanted with force transducers. Viscosities of the SDFs were measured using a viscosimeter.
resultsIn cats given RFD-Dry, IND (3 mg/kg) increased motility and produced many lesions in the lower half of the small intestine; the total lesion area (TLA) was 7.5 +/- 2.6 cm(2) (n = 4). Lesions induced by IND were markedly decreased in cats given RFD-Dry supplemented with 3% pectin, guar gum, polydextrose or mucin; TLAs were 0.6 +/- 0.3, 0.0 +/- 0.0, 1.3 +/- 0.8 and 1.6 +/- 0.5 cm(2) (n = 4) (P < 0.05 vs. RFD-Dry alone), respectively. The viscosity (mPa-S) of pectin, guar gum, polydextrose and mucin (3% concentration) was 414, >1,200, 1 and 4, respectively. Pectin did not affect the absorption of IND nor did it inhibit IND-induced intestinal hypermotility.
conclusionsSDFs protect the small intestine against NSAID-induced damage, probably by compensating a barrier function of the mucin decreased by IND. Viscosities of the SDFs play a role, at least in part, in the protective effects of the SDFs on the small intestine.
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