ArticleMolecular and cellular biochemistry2009
Alterations in peroxisome proliferator-activated receptor mRNA expression in skeletal muscle after acute and repeated bouts of exercise.
Article in Molecular and cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine.Scientific reports · 2022Pooled it
- Exercise-induced BDNF promotes PPARδ-dependent reprogramming of lipid metabolism in skeletal muscle during exercise recovery.Science signaling · 2024Article
- Flight and Dietary Antioxidants Influence Antioxidant Expression and Activity in a Migratory Bird.Integrative organismal biology (Oxford, England) · 2022Article
- Plasma Interleukin-10 and Cholesterol Levels May Inform about Interdependences between Fitness and Fatness in Healthy Individuals.International journal of environmental research and public health · 2021Article
- Resistance training regulates gene expression of molecules associated with intramyocellular lipids, glucose signaling and fiber size in old rats.Scientific reports · 2017Article
- PPARγ regulates inflammatory reaction by inhibiting the MAPK/NF-κB pathway in C2C12 skeletal muscle cells.Journal of physiology and biochemistry · 2017Article
- The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.Physiological reviews · 2015Review
- Transcriptional modulation of mitochondria biogenesis pathway at and above critical speed in mice.Molecular and cellular biochemistry · 2015Article
- Activation of PPARδ signaling improves skeletal muscle oxidative metabolism and endurance function in an animal model of ischemic left ventricular dysfunction.American journal of physiology. Heart and circulatory physiology · 2015Article
- Influence of cardiorespiratory fitness on PPARG mRNA expression using monozygotic twin case control.Journal of diabetes research · 2015Article
- Mechanisms governing the health and performance benefits of exercise.British journal of pharmacology · 2013Review
- Exercise alters mRNA expression of telomere-repeat binding factor 1 in skeletal muscle via p38 MAPK.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Myogenin regulates exercise capacity and skeletal muscle metabolism in the adult mouse.PloS one · 2010Article
- Nitric Oxide contributes to the regulation of iron metabolism in skeletal muscle in vivo and in vitro.Molecular and cellular biochemistry · 2010Article
- Women have higher protein content of beta-oxidation enzymes in skeletal muscle than men.PloS one · 2010Article
- Effect of chronic contractile activity on mRNA stability in skeletal muscle.American journal of physiology. Cell physiology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Peroxisome proliferator-activated receptors (PPAR) exist in three different forms, alpha (alpha), beta/delta (beta/delta), or gamma (gamma), all of which are expressed in skeletal muscle and play a critical role in the regulation of oxidative metabolism. The purpose of this investigation was to determine the mRNA expression pattern of the different PPARs and peroxisome proliferator-activated receptor alpha coactivator-1 alpha (PGC-1alpha) in muscles that largely rely on either glycolytic (plantaris) or oxidative (soleus) metabolism. Further, we also examined the alterations in the PPARs mRNA expression after one bout of endurance exercise or after 12 weeks of exercise training in the different muscles. Female Sprague-Dawley rats (5-8 months) were either run on the treadmill once or exercised trained for 12 weeks. The muscles were removed 24 h after the last bout of exercise. The results demonstrated with the exception of PPAR beta/delta, the PPAR mRNAs are expressed to a greater extent in the soleus muscle than in the plantaris muscle in sedentary animals. PPARgamma was the least abundantly expressed PPAR in either the soleus or the plantaris muscle. With respect to exercise training, only PPARgamma mRNA expression increased in the soleus muscle, while PPARbeta/delta and gamma mRNA levels increased in the plantaris muscle. Minimal changes were detected in any of the PPARs with one bout of exercise training. These results suggest that PPARgamma mRNA levels are the lowest in skeletal muscle among all of the PPARs and PPARgamma mRNA is the most responsive to changes in physical activity levels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.