SynthesisRheumatology international2010
Association between the rs7574865 polymorphism of STAT4 and rheumatoid arthritis: a meta-analysis.
Synthesis in Rheumatology international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients.Annals of the rheumatic diseases · 2012Pooled it
- Polymorphisms in the CTLA-4 gene and rheumatoid arthritis susceptibility: a meta-analysis.Journal of clinical immunology · 2012Pooled it
- Meta-analysis of 125 rheumatoid arthritis-related single nucleotide polymorphisms studied in the past two decades.PloS one · 2012Pooled it
- Article
- Influence ofJournal of clinical medicine · 2024Article
- Fine-Tuning Cytokine Signals.Annual review of immunology · 2019Review
- Understanding the major risk factors in the beginning and the progression of rheumatoid arthritis: current scenario and future prospects.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Review
- Article
- Rheumatoid arthritis susceptibility genes: An overview.World journal of orthopedics · 2014Review
- Association of susceptible genetic markers and autoantibodies in rheumatoid arthritis.Journal of genetics · 2014Review
- Association of STAT4 gene rs7574865G > T polymorphism with ulcerative colitis risk: evidence from 1532 cases and 3786 controls.Archives of medical science : AMS · 2014Review
- Contribution of STAT4 gene single-nucleotide polymorphism to systemic lupus erythematosus in the Polish population.Molecular biology reports · 2012Article
- A single-nucleotide polymorphism of the STAT4 gene is associated with systemic lupus erythematosus (SLE) in female Chinese population.Rheumatology international · 2012Article
- A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.Annals of the rheumatic diseases · 2011Article
- Genetics of rheumatoid arthritis: GWAS and beyond.Open access rheumatology : research and reviews · 2011Review
- A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis.PloS one · 2011Article
- Pharmacogenetics of rheumatoid arthritis: Potential targets from susceptibility genes and present therapies.Pharmacogenomics and personalized medicine · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to determine whether the rs7574865 polymorphism of STAT4 (signal transducers and activators of transcription 4) confers susceptibility to rheumatoid arthritis (RA) in populations with different ethnicities. A meta-analysis was conducted on the T allele of the STAT4 rs7574865 polymorphism in 15 studies containing 16,088 RA patients and 16,509 normal control subjects. Meta-analysis revealed an association between RA and the STAT4 rs7574865 T allele in all subjects (OR = 1.271, 95% CI = 1.197-1.350, P < 0.001). Furthermore, the STAT4 rs7574865 T allele was found to be significantly associated with RA in Europeans and Asians (OR = 1.300, 95% CI = 1.195-1.414, P < 0.001; OR = 1.216, 95% CI = 1.135-1.303, P < 0.001). Stratification of RA patients according to the presence of anti-CCP antibody revealed a statistically significant association between the T allele and RA in both anti-CCP-positive and -negative RA patients versus controls. Europeans had the lowest (21.4%) and Asians had the highest (32.0%) prevalence of the T allele among the populations studied. In conclusion, this meta-analysis confirms that the STAT4 rs7574865 polymorphism is associated with RA susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.