ArticleCellular and molecular life sciences : CMLS2009
The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase.
Article in Cellular and molecular life sciences : CMLS, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Functional remodeling of gut microbiota and liver in laying hens as affected by fasting and refeeding after fasting.Animal bioscience · 2025Article
- The tree of life of copper-containing amine oxidases.Frontiers in plant science · 2025Article
- Expression of Amine Oxidase Proteins in Adrenal Cortical Neoplasm and Pheochromocytoma.Biomedicines · 2023Article
- Spatially Distinct Genetic Determinants of Aortic Dimensions Influence Risks of Aneurysm and Stenosis.Journal of the American College of Cardiology · 2022Article
- High doses of tyramine stimulate glucose transport in human fat cells.Journal of physiology and biochemistry · 2022Article
- Vascular adhesion protein-1 and microvascular diabetic complications.Pharmacological reports : PR · 2022Review
- Review
- Human Copper-Containing Amine Oxidases in Drug Design and Development.Molecules (Basel, Switzerland) · 2020Review
- Derangement of Metabolic and Lysosomal Gene Profiles in Response to Dexamethasone Treatment in Sarcoidosis.Frontiers in immunology · 2020Article
- A Prognostic Model Based on Six Metabolism-Related Genes in Colorectal Cancer.BioMed research international · 2020Article
- Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines.Nature communications · 2019Article
- Vascular Adhesion Protein-1: A Cell Surface Amine Oxidase in Translation.Antioxidants & redox signaling · 2019Review
- Human copper-dependent amine oxidases.Archives of biochemistry and biophysics · 2014Review
- Article
- Vasoconstrictor and vasodilator responses to tryptamine of rat-isolated perfused mesentery: comparison with tyramine and β-phenylethylamine.British journal of pharmacology · 2012Article
- The role of protein crystallography in defining the mechanisms of biogenesis and catalysis in copper amine oxidase.International journal of molecular sciences · 2012Article
- Implication for functions of the ectopic adipocyte copper amine oxidase (AOC3) from purified enzyme and cell-based kinetic studies.PloS one · 2012Article
- A new crystal form of human vascular adhesion protein 1.Acta crystallographica. Section F, Structural biology and crystallization communications · 2010Article
- Structure and inhibition of human diamine oxidase.Biochemistry · 2009Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Semicarbazide-sensitive amine oxidases (SSAOs) catalyze oxidative deamination of primary amines, but the true physiological function of these enzymes is still poorly understood. Here, we have studied the functional and structural characteristics of a human cell-surface SSAO, AOC2, which is homologous to the better characterized family member, AOC3. The preferred in vitro substrates of AOC2 were found to be 2-phenylethylamine, tryptamine and p-tyramine instead of methylamine and benzylamine, the favored substrates of AOC3. Molecular modeling suggested structural differences between AOC2 and AOC3, which provide AOC2 with the capability to use the larger monoamines as substrates. Even though AOC2 mRNA was expressed in many tissues, the only tissues with detectable AOC2-like enzyme activity were found in the eye. Characterization of AOC2 will help in evaluating the contribution of this enzyme to the pathological processes attributed to the SSAO activity and in designing specific inhibitors for the individual members of the SSAO family.
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