ArticlePloS one2009
Biophysical mechanism for ras-nanocluster formation and signaling in plasma membrane.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- HIV-1 envelope glycoprotein modulates CXCR4 clustering and dynamics on the T cell membrane.eLife · 2026Article
- Positive feedback in Ras activation by full-length SOS arises from autoinhibition release mechanism.Biophysical journal · 2024Article
- Altered CXCR4 dynamics at the cell membrane impairs directed cell migration in WHIM syndrome patients.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- γ-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion.Langmuir : the ACS journal of surfaces and colloids · 2020Article
- Shared behavioral mechanisms underlieeLife · 2019Article
- A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS.Science (New York, N.Y.) · 2019Article
- A Rationale for Mesoscopic Domain Formation in Biomembranes.Biomolecules · 2018Article
- A critical-like collective state leads to long-range cell communication in Dictyostelium discoideum aggregation.PLoS biology · 2017Article
- On characterizing protein spatial clusters with correlation approaches.Scientific reports · 2016Article
- Cooperative Clustering Digitizes Biochemical Signaling and Enhances its Fidelity.Biophysical journal · 2016Article
- Modeling curvature-dependent subcellular localization of the small sporulation protein SpoVM in Bacillus subtilis.PloS one · 2015Article
- The efficacy of Raf kinase recruitment to the GTPase H-ras depends on H-ras membrane conformer-specific nanoclustering.The Journal of biological chemistry · 2014Article
- Spatial partitioning improves the reliability of biochemical signaling.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Membrane clustering and the role of rebinding in biochemical signaling.Biophysical journal · 2012Article
- A bistable model of cell polarity.PloS one · 2012Article
- A density-dependent switch drives stochastic clustering and polarization of signaling molecules.PLoS computational biology · 2011Article
- Roles of the cytoskeleton in regulating EphA2 signals.Communicative & integrative biology · 2010Article
- Chemotactic response and adaptation dynamics in Escherichia coli.PLoS computational biology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Ras GTPases are lipid-anchored G proteins, which play a fundamental role in cell signaling processes. Electron micrographs of immunogold-labeled Ras have shown that membrane-bound Ras molecules segregate into nanocluster domains. Several models have been developed in attempts to obtain quantitative descriptions of nanocluster formation, but all have relied on assumptions such as a constant, expression-level independent ratio of Ras in clusters to Ras monomers (cluster/monomer ratio). However, this assumption is inconsistent with the law of mass action. Here, we present a biophysical model of Ras clustering based on short-range attraction and long-range repulsion between Ras molecules in the membrane. To test this model, we performed Monte Carlo simulations and compared statistical clustering properties with experimental data. We find that we can recover the experimentally-observed clustering across a range of Ras expression levels, without assuming a constant cluster/monomer ratio or the existence of lipid rafts. In addition, our model makes predictions about the signaling properties of Ras nanoclusters in support of the idea that Ras nanoclusters act as an analog-digital-analog converter for high fidelity signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.