Evidence map›Paper›PMID 19587639›Full record

ReviewMucosal immunology2009

Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa.

S A Khader, S L Gaffen, J K Kolls

Open access · bronzeAbstract readReview
In one paragraph

Review in Mucosal immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 264 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
264citing papers in PubMed, 1 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

264 citing papers in PubMed, 1 synthesis or guideline pooled it, 469 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
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  5. Trial
  6. Article
  7. Review
  8. Article
  9. Fungal Infections in Disorders of Inborn Errors of Immunity.Clinical reviews in allergy & immunology · 2026
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Transcriptomic insights intoThe veterinary quarterly · 2025
    Article

204 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

S A KhaderDepartment of Pediatrics (Pulmonology) and Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
S L Gaffen
J K Kolls
University of Pittsburgh · US

Funding

Surrogate Biomarkers for Disease Progression in IPFP50HL084932 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, ANURADHA · 2006 to 2010
$12.2M
Th17 Cytokines and Lung ImmunityR37HL079142 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLLS, JAY K · 2010 to 2017
$3.6M
IL-23 / Il-17 and Lung Host DefenseR01HL079142 · NHLBI · LSU HEALTH SCIENCES CENTER · PI KOLLS, JAY K · 2005 to 2009
$1.9M
Structure-Function Relationships in the IL-17 ReceptorR01AR054389 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2008 to 2012
$1.8M
Novel IL-17 producing memory cells are key to vaccine-based immunity in the lungR00AI075106 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KHADER, SHABAANA A. · 2008 to 2009
$486k
Immunity to Oral CandidiasisR21DE018822 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2008 to 2009
$417k
NHLBI NIH HHS P50HL084932NHLBI NIH HHS R01HL079142NHLBI NIH HHS R37 HL079142NIAID NIH HHS R00 AI075106NIAID NIH HHS R00AI075106NIAMS NIH HHS AR054389NIAMS NIH HHS R01 AR054389NIDCR NIH HHS DE018822NIDCR NIH HHS R21 DE018822
6 · The paper itself

Abstract

T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in autoimmunity is well documented, there is growing evidence that the Th17 lineage and other interleukin (IL)-17-producing cells are critical for host defense against bacterial, fungal, and viral infections at mucosal surfaces. Here we summarize recent progress in our understanding of the function of IL-17-producing cells as a bridge between innate and adaptive immunity against infectious diseases at the mucosa.

Indexed as

AnimalsCell LineageHumansImmunity, InnateImmunologic Deficiency SyndromesImmunotherapyInfectionsInterleukinsLymphocyte CooperationMiceMice, KnockoutModels, ImmunologicalMucous MembraneReceptors, Interleukin-17Signal TransductionT-Lymphocytes, Helper-InducerIL17RA protein, humanIl17ra protein, mouseInterleukinsReceptors, Interleukin-17Tumor Necrosis Factor-alpha

Identifiers

PMID19587639
PMCPMC2811522
OpenAlexW2070171027

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.