ReviewCurrent opinion in ophthalmology2009
Myopia genetics: a review of current research and emerging trends.
Review in Current opinion in ophthalmology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 132 citations in OpenAlex.
- Meta-analysis of the association between lumican gene polymorphisms and susceptibility to high Myopia.PloS one · 2014Pooled it
- Genetic influence on choroidal vascularity index.PloS one · 2025Article
- Crosstalk between Myopia and Inflammation: A Mini Review.International journal of medical sciences · 2024Review
- Whole-Exome Sequencing Among School-Aged Children With High Myopia.JAMA network open · 2023Article
- Clinical observation of posterior scleral reinforcement in the treatment of progressive high myopia in Chinese children: a retrospective study.BMC ophthalmology · 2022Article
- Genetic susceptibility to high myopia in Han Chinese population.Open life sciences · 2022Article
- Air Pollutant Particles, PMInternational journal of environmental research and public health · 2021Article
- Article
- Pure ICL Implantation: A Novel Ophthalmic Viscosurgical Device-Free Method.Journal of ophthalmology · 2021Article
- Mutational screening ofMolecular vision · 2021Article
- Heritability of Inner Retinal Layer and Outer Retinal Layer Thickness: The Healthy Twin Study.Scientific reports · 2020Article
- Prevalence of and risk factors for refractive error: a cross-sectional study in Han and Mongolian adults aged 40-80 years in Inner Mongolia, China.Eye (London, England) · 2019Article
- Evaluation of visual quality after EVO-ICL implantation for hypermyopia: An observational study.Medicine · 2019Observational
- Choriocapillaris Degeneration in Geographic Atrophy.The American journal of pathology · 2019Article
- IMI - Myopia Genetics Report.Investigative ophthalmology & visual science · 2019Review
- Comparison of visual quality after EVO-ICL implantation and SMILE to select the appropriate surgical method for high myopia.BMC ophthalmology · 2019Article
- Prevalence and risk factors of refractive error: a cross-sectional Study in Han and Yi adults in Yunnan, China.BMC ophthalmology · 2019Article
- Differential stability of variantMolecular vision · 2019Article
- Missense mutation in SLIT2 associated with congenital myopia, anisometropia, connective tissue abnormalities, and obesity.Orphanet journal of rare diseases · 2018Article
- Müller glia-derived PRSS56 is required to sustain ocular axial growth and prevent refractive error.PLoS genetics · 2018Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
purpose of reviewMyopia, or nearsightedness, is the most common human eye disorder in the world and is a significant global public health concern. Along with cataract, macular degeneration, infectious disease, and vitamin A deficiency, myopia is one of the most important causes of visual impairment worldwide. Severe or high-grade myopia is a leading cause of blindness because of its associated ocular comorbidities of retinal detachment, macular choroidal degeneration, premature cataract, and glaucoma. Ample epidemiologic and molecular genetic studies support heritability of the nonsyndromic forms of this condition. RECENT
findingsMultiple myopia genetic loci have been identified, establishing this entity as a common complex disorder and underscoring the suitability for gene inquiry studies. Animal model research, primarily using form-deprivation techniques, implicates multiple altered regulation of biological substances in the ocular wall layers, which provides important information for prioritizing human candidate gene studies. Recent epidemiologic work supports a greater role for outdoor activity in relieving myopia progression rather than the previous touted young-age near-work activity model. SUMMARY: The identification of myopia susceptibility genes will not only provide insight into the molecular basis of this significant eye disorder, but will also identify pathways involved in eye growth and development. This effort may lead to effective therapies to treat or potentially prevent this common eye condition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.