ArticleJournal of neurophysiology2009
Genetic dissection of rod and cone pathways in the dark-adapted mouse retina.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.Nature genetics · 2013Pooled it
- Rod/Cone Gap Junctions: Plastic Electrical Synapses at the First Visual Synapse.Annual review of vision science · 2026Review
- Ankyrin-B and ankyrin-G are required for synaptic integrity in the mouse outer retina.PNAS nexus · 2026Article
- Cerebral Hypoperfusion Causes Behavioral Changes and Impairs the Rod Photoreceptor Pathway in the Retina of Aged Mice.Cellular and molecular neurobiology · 2026Article
- Inhibition of connexin hemichannels protects retinal ganglion cells against ocular nerve injury.Cellular and molecular life sciences : CMLS · 2026Article
- The Retinal Light Response Is Modulated by an mGluR5-Mediated Retrograde Signal from ON-Bipolar Cells to Photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The retinal light response is modulated by an mGluR5-mediated retrograde signal from ON-bipolar cells to photoreceptors.bioRxiv : the preprint server for biology · 2025Article
- Linear and Nonlinear Behaviors of the Photoreceptor Coupled Network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- TRPV4 affects visual signals in photoreceptors and rod bipolar cells.Frontiers in cellular neuroscience · 2024Article
- Functional and structural changes in the neuroretina are accompanied by mitochondrial dysfunction in a type 2 diabetic mouse model.Eye and vision (London, England) · 2023Article
- βII-Spectrin Is Required for Synaptic Positioning during Retinal Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Chromophore supply modulates cone function and survival in retinitis pigmentosa mouse models.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Multiple Bioenergy-Linked OCT Biomarkers Suggest Greater-Than-Normal Rod Mitochondria Activity Early in Experimental Alzheimer's Disease.Investigative ophthalmology & visual science · 2023Article
- Transducin-Deficient Rod Photoreceptors Evaluated With Optical Coherence Tomography and Oxygen Consumption Rate Energy Biomarkers.Investigative ophthalmology & visual science · 2022Article
- Circadian Regulation of the Rod Contribution to Mesopic Vision in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Genetic elimination of rod/cone coupling reveals the contribution of the secondary rod pathway to the retinal output.Science advances · 2022Article
- Function of cone and cone-related pathways in CaScientific reports · 2021Article
- Neurofascin Is a Novel Component of Rod Photoreceptor Synapses in the Outer Retina.Frontiers in neural circuits · 2021Article
- Expression and distribution of trophoblast glycoprotein in the mouse retina.The Journal of comparative neurology · 2020Article
- Genetic dissection of rod and cone pathways mediating light responses and receptive fields of ganglion cells in the mouse retina.Vision research · 2020Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
A monumental task of the mammalian retina is to encode an enormous range (>10(9)-fold) of light intensities experienced by the animal in natural environments. Retinal neurons carry out this task by dividing labor into many parallel rod and cone synaptic pathways. Here we study the operational plan of various rod- and cone-mediated pathways by analyzing electroretinograms (ERGs), primarily b-wave responses, in dark-adapted wildtype, connexin36 knockout, depolarizing rod-bipolar cell (DBCR) knockout, and rod transducin alpha-subunit knockout mice [WT, Cx36(-/-), Bhlhb4(-/-), and Tralpha(-/-)]. To provide additional insight into the cellular origins of various components of the ERG, we compared dark-adapted ERG responses with response dynamic ranges of individual retinal cells recorded with patch electrodes from dark-adapted mouse retinas published from other studies. Our results suggest that the connexin36-mediated rod-cone coupling is weak when light stimulation is weak and becomes stronger as light stimulation increases in strength and that rod signals may be transmitted to some DBCCs via direct chemical synapses. Moreover, our analysis indicates that DBCR responses contribute about 80% of the overall DBC response to scotopic light and that rod and cone signals contribute almost equally to the overall DBC responses when stimuli are strong enough to saturate the rod bipolar cell response. Furthermore, our study demonstrates that analysis of ERG b-wave of dark-adapted, pathway-specific mutants can be used as an in vivo tool for dissecting rod and cone synaptic pathways and for studying the functions of pathway-specific gene products in the retina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.