ArticleJournal of neurophysiology2009
Origins of abnormal excitability in biceps brachii motoneurons of spastic-paretic stroke survivors.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
65 citing papers in PubMed, 129 citations in OpenAlex.
- Trial
- Concurrent neuromechanical and functional gains following upper-extremity power training post-stroke.Journal of neuroengineering and rehabilitation · 2013Trial
- The relationship between the flexion synergy and stretch reflexes in individuals with chronic hemiparetic stroke.IEEE ... International Conference on Rehabilitation Robotics : [proceedings] · 2011Trial
- Review
- Pathophysiology of voluntary motor commands at the level of the spinal motoneuron in patients with multiple sclerosis.medRxiv : the preprint server for health sciences · 2025Article
- Excitation-inhibition imbalance in the motor control network: a key factor in post-stroke spasticity.Frontiers in human neuroscience · 2025Review
- Measurement properties of movement smoothness metrics for upper limb reaching movements in people with moderate to severe subacute stroke.Journal of neuroengineering and rehabilitation · 2024Article
- Motor unit firing rate modulation is more impaired during flexion synergy-driven contractions of the biceps brachii in chronic stroke.medRxiv : the preprint server for health sciences · 2023Article
- Altered flexor carpi radialis motor axon excitability properties after cerebrovascular stroke.Frontiers in neurology · 2023Article
- Effects of reciprocal inhibition and whole-body relaxation on persistent inward currents estimated by two different methods.The Journal of physiology · 2022Article
- Observational
- Electrical Properties of Adult Mammalian Motoneurons.Advances in neurobiology · 2022Article
- The Cellular Basis for the Generation of Firing Patterns in Human Motor Units.Advances in neurobiology · 2022Article
- Concurrent Achilles tendon vibration and tibial nerve stimulation to estimate persistent inward current strength in motoneurons.European journal of translational myology · 2021Article
- Article
- Differences in estimated persistent inward currents between ankle flexors and extensors in humans.Journal of neurophysiology · 2020Article
- Quantifying Altered Neural Connectivity of the Stretch Reflex in Chronic Hemiparetic Stroke.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2020Article
- Impact of parameter selection on estimates of motoneuron excitability using paired motor unit analysis.Journal of neural engineering · 2020Article
- Nonlinear Input-Output Functions of Motoneurons.Physiology (Bethesda, Md.) · 2020Review
- Stretch reflex excitability in contralateral limbs of stroke survivors is higher than in matched controls.Journal of neuroengineering and rehabilitation · 2019Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Stroke survivors often exhibit abnormal motoneuron excitability, manifested clinically as spasticity with exaggerated stretch reflexes in resting muscles. We examined whether this abnormal excitability is a result of increased activation of intrinsic voltage-dependent persistent inward currents (PICs) or whether it is a result of enhanced synaptic inputs to the motoneuron. This distinction was made by recording firing rate profiles of pairs of motor units during isometric contractions of elbow flexor muscles. To estimate PIC amplitude, the discharge of the lower-threshold (reporter) motor unit of the pair was used to estimate the synaptic input to the higher-threshold (test) motor unit. The estimated synaptic input required to recruit the test unit was compared with the synaptic input when the test unit was derecruited (DeltaF) and this served as an estimate of the intrinsic (PIC) contribution to motoneuron firing. We found that PIC estimates were not larger in spastic-paretic motoneurons (DeltaF = 4.0 +/- 1.6 pps) compared with contralateral (4.6 +/- 1.4 pps) and age-matched healthy control motoneurons (3.8 +/- 1.7, all P > 0.1). Instead, following the voluntary contractions, the majority of lower-threshold motor units in spastic-paretic muscles (83%) exhibited spontaneous discharge, compared with 14% of contralateral and 0% of control motor units. Furthermore, there was strong co-modulation of simultaneously active units in spastic muscle. The presence of ongoing, correlated unit activity at "rest," coupled with firing behavior at recruitment unique to lower-threshold motor units in spastic muscles, suggested that firing changes are likely a result of a low-level depolarizing synaptic drive to the resting motoneuron pool.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.