ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Activity-dependent codevelopment of the corticospinal system and target interneurons in the cervical spinal cord.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 63 citations in OpenAlex.
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- Skilled Bimanual Training Drives Motor Cortex Plasticity in Children With Unilateral Cerebral Palsy.Neurorehabilitation and neural repair · 2016Trial
- Multimodal MRI of white matter development and selective motor control in preterm infants.NeuroImage. Clinical · 2026Article
- The role of independent walking in the maturation of the spinal locomotor output in children with cerebral palsy.Frontiers in physiology · 2026Article
- Synaptic imbalance and increased inhibition impair motor function in SMA.Science advances · 2025Article
- Thoracic Spinal Cord Contusion Impacts on Lumbar Enlargement: Molecular Insights.Molecular neurobiology · 2025Article
- Motor patterns of patients with spinal muscular atrophy suggestive of sensory and corticospinal contributions to the development of locomotor muscle synergies.Journal of neurophysiology · 2024Article
- A neural tract tracing study on synaptic connections for cortical glutamatergic terminals and cervical spinal calretinin neurons in rats.Frontiers in neural circuits · 2023Article
- A computational model based on corticospinal functional MRI revealed asymmetrically organized motor corticospinal networks in humans.Communications biology · 2022Article
- Greater Reliance on Cerebral Palsy-Specific Muscle Synergies During Gait Relates to Poorer Temporal-Spatial Performance Measures.Frontiers in physiology · 2021Article
- Spinal motoneuron firing properties mature from rostral to caudal during postnatal development of the mouse.The Journal of physiology · 2020Article
- Maturation of the Locomotor Circuitry in Children With Cerebral Palsy.Frontiers in bioengineering and biotechnology · 2020Review
- Higher primate-like direct corticomotoneuronal connections are transiently formed in a juvenile subprimate mammal.Scientific reports · 2018Article
- Transneuronal Downregulation of the Premotor Cholinergic System After Corticospinal Tract Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Stimulation-dependent remodeling of the corticospinal tract requires reactivation of growth-promoting developmental signaling pathways.Experimental neurology · 2018Article
- False-Positive and False-Negative Results of Motor Evoked Potential Monitoring During Surgery for Intramedullary Spinal Cord Tumors.Operative neurosurgery (Hagerstown, Md.) · 2018Article
- Motor system plasticity after unilateral injury in the developing brain.Developmental medicine and child neurology · 2017Review
- Participatory design in the development of an early therapy intervention for perinatal stroke.BMC pediatrics · 2017Article
- Developmental changes in intralimb coordination during spontaneous movements of human infants from 2 to 3 months of age.Experimental brain research · 2016Article
- Competition with Primary Sensory Afferents Drives Remodeling of Corticospinal Axons in Mature Spinal Motor Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Corticospinal tract (CST) connections to spinal interneurons are conserved across species. We identified spinal interneuronal populations targeted by the CST in the cervical enlargement of the cat during development. We focused on the periods before and after laminar refinement of the CST terminations, between weeks 5 and 7. We used immunohistochemistry of choline acetyltransferase (ChAT), calbindin, calretinin, and parvalbumin to mark interneurons. We first compared interneuron marker distribution before and after CST refinement. ChAT interneurons increased, while calbindin interneurons decreased during this period. No significant changes were noted in parvalbumin and calretinin. We next used anterograde labeling to determine whether the CST targets different interneuron populations before and after the refinement period. Before refinement, the CST terminated sparsely where calbindin interneurons were located and spared ChAT interneurons. After refinement, the CST no longer terminated in calbindin-expressing areas but did so where ChAT interneurons were located. Remarkably, early CST terminations were dense where ChAT interneurons later increased in numbers. Finally, we determined whether corticospinal system activity was necessary for the ChAT and calbindin changes. We unilaterally inactivated M1 between weeks 5 and 7 by muscimol infusion. Inactivation resulted in a distribution of calbindin and ChAT in spinal gray matter regions where the CST terminates that resembled the immature more than mature pattern. Our results show that the CST plays a crucial role in restructuring spinal motor circuits during development, possibly through trophic support, and provide strong evidence for the importance of connections with key spinal interneuron populations in development of motor control functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.