ArticleJournal of virology2009
Transcriptional changes in the brains of cattle orally infected with the bovine spongiform encephalopathy agent precede detection of infectivity.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Accurate Genomic Predictions for Chronic Wasting Disease in U.S. White-Tailed Deer.G3 (Bethesda, Md.) · 2020Article
- RNA editing alterations define manifestation of prion diseases.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Whole Blood Gene Expression Profiling in Preclinical and Clinical Cattle Infected with Atypical Bovine Spongiform Encephalopathy.PloS one · 2016Article
- Gene expression profiling of brains from bovine spongiform encephalopathy (BSE)-infected cynomolgus macaques.BMC genomics · 2014Article
- Comparative analysis of gene expression profiles between cortex and thalamus in Chinese fatal familial insomnia patients.Molecular neurobiology · 2013Article
- Functional genomics approach for identification of molecular processes underlying neurodegenerative disorders in prion diseases.Current genomics · 2012Article
- Central nervous system gene expression changes in a transgenic mouse model for bovine spongiform encephalopathy.Veterinary research · 2011Article
- Transcriptional analysis implicates endoplasmic reticulum stress in bovine spongiform encephalopathy.PloS one · 2010Article
- Application of "omics" to prion biomarker discovery.Journal of biomedicine & biotechnology · 2010Review
- Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells.The Journal of biological chemistry · 2009Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine spongiform encephalopathy (BSE) is a fatal, transmissible, neurodegenerative disease of cattle. BSE can be transmitted experimentally between cattle through the oral route, and in this study, brain tissue samples from animals at different time points postinoculation were analyzed for changes in gene expression. The aims of this study were to identify differentially regulated genes during the progression of BSE using microarray-based gene expression profiling and to understand the effect of prion pathogenesis on gene expression. A total of 114 genes were found to be differentially regulated over the time course of the infection, and many of these 114 genes encode proteins involved in immune response, apoptosis, cell adhesion, stress response, and transcription. This study also revealed a broad correlation between gene expression profiles and the progression of BSE in cattle. At 21 months postinoculation, the largest number of differentially regulated genes was detected, suggesting that there are many pathogenic processes in the animal brain even prior to the detection of infectivity in the central nervous systems of these orally infected cattle. Moreover, evidence is presented to suggest that it is possible to predict the infectious status of animals using the expression profiles from this study.
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Registered trials
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