ArticleJournal of immunology (Baltimore, Md. : 1950)2009
IL-13 receptor alpha2 regulates the immune and functional response to Nippostrongylus brasiliensis infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Prevalence and resistance to gastrointestinal parasites in goats: A review.Veterinary world · 2022Review
- Effects of Epithelial IL-13Rα2 Expression in Inflammatory Bowel Disease.Frontiers in immunology · 2018Article
- Critical Role for Interleukin-25 in Host Protective Th2 Memory Response against Heligmosomoides polygyrus bakeri.Infection and immunity · 2016Article
- Mechanisms Involved in the Development of the Chronic Gastrointestinal Syndrome in Nonhuman Primates after Total-Body Irradiation with Bone Marrow Shielding.Radiation research · 2016Article
- Interleukin-13 Receptor α1-Dependent Responses in the Intestine Are Critical to Parasite Clearance.Infection and immunity · 2016Article
- The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension.American journal of respiratory and critical care medicine · 2015Article
- Type 2 immunity-dependent reduction of segmented filamentous bacteria in mice infected with the helminthic parasite Nippostrongylus brasiliensis.Microbiome · 2015Article
- Commentary: IL-4 and IL-13 receptors and signaling.Cytokine · 2015Article
- Type 2 cytokines: mechanisms and therapeutic strategies.Nature reviews. Immunology · 2015Review
- IL-13 receptor α2 contributes to development of experimental allergic asthma.The Journal of allergy and clinical immunology · 2013Article
- SerpinB2 is critical to Th2 immunity against enteric nematode infection.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- IL-33-induced alterations in murine intestinal function and cytokine responses are MyD88, STAT6, and IL-13 dependent.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity.PloS one · 2013Article
- Signal transducer and activator of transcription factor 6 signaling contributes to control host lung pathology but favors susceptibility against Toxocara canis infection.BioMed research international · 2013Article
- Mechanisms of smooth muscle responses to inflammation.Neurogastroenterology and motility · 2012Review
- Concomitant influence of helminth infection and landscape on the distribution of Puumala hantavirus in its reservoir, Myodes glareolus.BMC microbiology · 2011Article
- Mapping mouse IL-13 binding regions using structure modeling, molecular docking, and high-density peptide microarray analysis.Proteins · 2011Article
- Critical role of IL-25 in nematode infection-induced alterations in intestinal function.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Enteric pathogens and gut function: Role of cytokines and STATs.Gut microbes · 2010Article
- IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathway.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
IL-13 has a prominent role in host defense against the gastrointestinal nematode Nippostrongylus brasiliensis; however, the role of IL-13Ralpha2 in the immune and functional response to enteric infection is not known. In the current study, we investigated changes in smooth muscle and epithelial cell function as well as alterations in gene expression of IL-13 and IL-4 and their receptors using laser-capture microdissection of specific cell types in the small intestine of N. brasiliensis-infected mice. An infection-induced up-regulation of IL-13Ralpha2 gene expression was confined to smooth muscle and was dependent on STAT6 and IL-13, but not on IL-4. In contrast, expression of IL-13Ralpha1 was reduced, indicating that changes in IL-13alpha2 expression serve to limit the biological effects of IL-13. The increased availability of IL-13 in IL-13Ralpha2(-/-) mice resulted in marked changes in constitutive epithelial and smooth muscle function. In addition, maximal changes in smooth muscle hypercontractility and epithelial cell resistance peaked earlier after infection in IL-13Ralpha2(-/-) compared with wild-type mice. This did not coincide with an earlier Th2 immune response as expression of IL-4 and IL-13 was attenuated in IL-13Ralpha2(-/-) mice and worm expulsion was similar to that of wild-type mice. These data show that IL-13Ralpha2 plays an important role in nematode infection by limiting the availability of IL-13 during infection, thereby regulating both the immune and biological effects of IL-13.
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