ArticleHaematologica2009
Heterogeneous breakpoints in patients with acute lymphoblastic leukemia and the dic(9;20)(p11-13;q11) show recurrent involvement of genes at 20q11.21.
Article in Haematologica, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Recurrent DNMT3B rearrangements are associated with unfavorable outcome in dicentric (9;20)-positive pediatric BCP-ALL.Leukemia · 2023Article
- Genetic Biomarkers and Their Clinical Implications in B-Cell Acute Lymphoblastic Leukemia in Children.International journal of molecular sciences · 2022Review
- The distinct roles of zinc finger CCHC-type (ZCCHC) superfamily proteins in the regulation of RNA metabolism.RNA biology · 2021Review
- Review
- The Clinical Utility of Optical Genome Mapping for the Assessment of Genomic Aberrations in Acute Lymphoblastic Leukemia.Cancers · 2021Article
- Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.The Kaohsiung journal of medical sciences · 2020Article
- Landscape of Tumor Suppressor Mutations in Acute Myeloid Leukemia.Journal of clinical medicine · 2020Review
- Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/Frontiers in oncology · 2020Article
- Differentiating between cancer and normal tissue samples using multi-hit combinations of genetic mutations.Scientific reports · 2019Article
- KIF3B protein expression loss correlates with metastatic ability of prostate cancer.American journal of clinical and experimental urology · 2019Article
- Integrated molecular characterization of adult soft tissue sarcoma for therapeutic targets.BMC medical genetics · 2018Article
- Advances in B-cell Precursor Acute Lymphoblastic Leukemia Genomics.HemaSphere · 2018Review
- Familial hematological malignancies: ASXL1 gene investigation.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016Article
- Long non-coding RNA and alternative splicing modulations in Parkinson's leukocytes identified by RNA sequencing.PLoS computational biology · 2014Article
- Article
- Clinical Correlates of Autosomal Chromosomal Abnormalities in an Electronic Medical Record-Linked Genome-Wide Association Study: A Case Series.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2013Article
- A new t(9;11;20;22)(q34;p11.2;q11.21;q11) in a Philadelphia-positive chronic myeloid leukemia case.Oncology letters · 2013Article
- Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases.Journal of hematology & oncology · 2012Review
- Air1 zinc knuckles 4 and 5 and a conserved IWRXY motif are critical for the function and integrity of the Trf4/5-Air1/2-Mtr4 polyadenylation (TRAMP) RNA quality control complex.The Journal of biological chemistry · 2011Article
- Article
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dic(9;20)(p11-13;q11) is a recurrent chromosomal abnormality in patients with acute lymphoblastic leukemia. Although it results in loss of material from 9p and 20q, the molecular targets on both chromosomes have not been fully elucidated. From an initial cohort of 58 with acute lymphoblastic leukemia patients with this translocation, breakpoint mapping with fluorescence in situ hybridization on 26 of them revealed breakpoint heterogeneity of both chromosomes. PAX5 has been proposed to be the target gene on 9p, while for 20q, FISH analysis implicated the involvement of the ASXL1 gene, either by a breakpoint within (n=4) or centromeric (deletion, n=12) of the gene. Molecular copy-number counting, long-distance inverse PCR and direct sequence analysis identified six dic(9;20) breakpoint sequences. In addition to the three previously reported: PAX5-ASXL1, PAX5-C20ORF112 and PAX5-KIF3B; we identified three new ones in this study: sequences 3' of PAX5 disrupting ASXL1, and ZCCHC7 disrupted by sequences 3' of FRG1B and LOC1499503. This study provides insight into the breakpoint complexity underlying dicentric chromosomal formation in acute lymphoblastic leukemia and highlights putative target gene loci.
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