ArticleJournal of medical genetics2010
Admixture mapping of ankle-arm index: identification of a candidate locus associated with peripheral arterial disease.
Article in Journal of medical genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Admixture mapping of peripheral artery disease in a Dominican population reveals a putative risk locus on 2q35.Frontiers in genetics · 2023Article
- Disparities in peripheral artery disease care: A review and call for action.Seminars in vascular surgery · 2022Review
- Genomics of disease risk in globally diverse populations.Nature reviews. Genetics · 2019Review
- Peripheral Arterial Disease Genetics: Progress to Date and Challenges Ahead.Current cardiology reports · 2017Review
- Evaluating genetic susceptibility to Staphylococcus aureus bacteremia in African Americans using admixture mapping.Genes and immunity · 2017Article
- Genetic ancestry is associated with measures of subclinical atherosclerosis in African Americans: the Jackson Heart Study.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Generalized admixture mapping for complex traits.G3 (Bethesda, Md.) · 2013Article
- A genome-wide admixture scan for ancestry-linked genes predisposing to sarcoidosis in African-Americans.Genes and immunity · 2011Article
- Development of admixture mapping panels for African Americans from commercial high-density SNP arrays.BMC genomics · 2010Article
- Mexican-American admixture mapping analyses for diabetic nephropathy in type 2 diabetes mellitus.Seminars in nephrology · 2010Article
- Admixture mapping comes of age.Annual review of genomics and human genetics · 2010Review
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundPeripheral arterial disease (PAD) is associated with significant morbidity and mortality, and has a higher prevalence in African Americans than Caucasians. Ankle-arm index (AAI) is the ratio of systolic blood pressure in the leg to that in the arm, and, when low, is a marker of PAD.
methodsThe authors used an admixture mapping approach to search for genetic loci associated with low AAI. Using data from 1040 African American participants in the observational, population based Health, Aging, and Body Composition Study who were genotyped at 1322 single nucleotide polymorphisms (SNPs) that are informative for African versus European ancestry and span the entire genome, we estimated genetic ancestry in each chromosomal region and then tested the association between AAI and genetic ancestry at each locus.
resultsThe authors found a region of chromosome 11 that reaches its peak between 80 and 82 Mb associated with low AAI (p<0.001 for rs12289502 and rs9665943, both within this region). 753 African American participants in the observational, population based Cardiovascular Health Study were genotyped at rs9665943 to test the reproducibility of this association, and this association was also statistically significant (odds ratio (OR) for homozygous African genotype 1.59, 95% confidence interval (CI) 1.12 to 2.27). Another candidate SNP (rs1042602) in the same genomic region was tested in both populations, and was also found to be significantly associated with low AAI in both populations (OR for homozygous African genotype 1.89, 95% CI 1.29 to 2.76).
conclusionThis study identifies a novel region of chromosome 11 representing an area with a potential candidate gene associated with PAD in African Americans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.