ArticleCancer letters2010
Ras activation contributes to the maintenance and expansion of Sca-1pos cells in a mouse model of breast cancer.
Article in Cancer letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Protein farnesylation: from molecular mechanisms to therapeutic targeting in cancer, aging, and beyond.Frontiers in pharmacology · 2026Review
- IKKβ Kinase Promotes Stemness, Migration, and Invasion in KRAS-Driven Lung Adenocarcinoma Cells.International journal of molecular sciences · 2020Article
- Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model.Cancers · 2019Review
- Genotoxic stress induces Sca-1-expressing metastatic mammary cancer cells.Molecular oncology · 2018Article
- Aberrantly regulated dysadherin and B-cell lymphoma 2/B-cell lymphoma 2-associated X enhances tumorigenesis and DNA targeting drug resistance of liver cancer stem cells.Molecular medicine reports · 2015Article
- ChIP-seq predicted estrogen receptor biding sites in human breast cancer cell line MCF7.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival.Oncogene · 2014Article
- Article
- Association between tumorigenic potential and the fate of cancer cells in a syngeneic melanoma model.PloS one · 2013Article
- Doxorubicin-enriched, ALDH(br) mouse breast cancer stem cells are treatable to oncolytic herpes simplex virus type 1.BMC cancer · 2012Article
- Dysadherin expression promotes the motility and survival of human breast cancer cells by AKT activation.Cancer science · 2012Article
- Inhibitor of DNA-binding 4 contributes to the maintenance and expansion of cancer stem cells in 4T1 mouse mammary cancer cell line.Laboratory animal research · 2011Article
- Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial-mesenchymal transition and nuclear factor-κB.Breast cancer research : BCR · 2011Article
- The role of breast cancer stem cells in metastasis and therapeutic implications.The American journal of pathology · 2011Review
- OCT4 Expression Enhances Features of Cancer Stem Cells in a Mouse Model of Breast Cancer.Laboratory animal research · 2011Article
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Authors and funding
12 authors.
Funding
Abstract
The cancer stem cell (CSC) hypothesis proposes that CSCs are the root of cancer and cause cancer metastasis and recurrence. In this study, we examined whether Ras signaling is associated with stemness of the CSCs population characterized by the stem cell antigen (Sca-1) phenotype in a 4T1 syngeneic mouse model of breast cancer. The Sca-1(pos) putative CSCs had high levels of activated Ras and phosphorylated MEK (p-MEK), compared with counterparts. The Ras farnesylation inhibitor (FTI-277) suppressed the maintenance and expansion of CSCs. Therefore, selective inhibition of Ras activation may be useful for stem-specific cancer therapy.
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