ReviewZeitschrift fur Rheumatologie2009
[Tissue retention of T cells as a therapeutic target in rheumatoid arthritis].
Review in Zeitschrift fur Rheumatologie, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors at 2 institutions in 1 country.
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Abstract
Autoreactive T cells are instrumental for the induction and chronification of autoimmune diseases. While immigration of T cells into inflamed tissue is strongly enhanced during acute inflammatory phases, retention of antigen specific T cells rather than subsequent recruitment of recirculating effector cells appears to contribute to the inflammatory infiltrate seen during chronic inflammation. Patients suffering from rheumatoid arthritis also show accumulation of oligoclonal T cells within the inflamed synovia, where environmental signals seem to promote the prolonged survival of these chronically activated T cells. The survival signals and mechanisms controlling retention of T cells within the inflamed synovia are poorly characterized. However, the specific interference with these mechanisms could be a therapeutic approach in chronic inflammatory diseases like rheumatoid arthritis that are accompanied by a strong local accumulation of immune cells.
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