ReviewCellular and molecular life sciences : CMLS2009
Predominant regulators of tubulin monomer-polymer partitioning and their implication for cell polarization.
Review in Cellular and molecular life sciences : CMLS, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Low Intensity Ultrasound as an Antidote to Taxane/Paclitaxel-induced Cytotoxicity.Journal of Cancer · 2022Review
- Persistent growth of microtubules at low density.Molecular biology of the cell · 2021Article
- Breaking malignant nuclei as a non-mitotic mechanism of taxol/paclitaxel.Journal of cancer biology · 2021Article
- The Protein Encoded by the CCDC170 Breast Cancer Gene Functions to Organize the Golgi-Microtubule Network.EBioMedicine · 2017Article
- MicroRNA-9 inhibits vasculogenic mimicry of glioma cell lines by suppressing Stathmin expression.Journal of neuro-oncology · 2013Article
- Stathmin and microtubules regulate mitotic entry in HeLa cells by controlling activation of both Aurora kinase A and Plk1.Molecular biology of the cell · 2013Article
- Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length.Journal of cell science · 2013Article
- Azaindole derivatives are inhibitors of microtubule dynamics, with anti-cancer and anti-angiogenic activities.British journal of pharmacology · 2013Article
- ErbB2-dependent chemotaxis requires microtubule capture and stabilization coordinated by distinct signaling pathways.PloS one · 2013Article
- Drosophila tubulin-binding cofactor B is required for microtubule network formation and for cell polarity.Molecular biology of the cell · 2012Article
- 4-hydroxy-2-nonenal mediates genotoxicity and bystander effects caused by Enterococcus faecalis-infected macrophages.Gastroenterology · 2012Article
- Microtubules support a disk-like septin arrangement at the plasma membrane of mammalian cells.Molecular biology of the cell · 2011Article
- Stimulation of the CLIP-170--dependent capture of membrane organelles by microtubules through fine tuning of microtubule assembly dynamics.Molecular biology of the cell · 2011Article
- Characterization and detection of cellular and proteomic alterations in stable stathmin-overexpressing, taxol-resistant BT549 breast cancer cells using offgel IEF/PAGE difference gel electrophoresis.Mutation research · 2011Article
- A novel role for progesterone and progesterone receptor membrane component 1 in regulating spindle microtubule stability during rat and human ovarian cell mitosis.Biology of reproduction · 2011Article
- RHAMM promotes interphase microtubule instability and mitotic spindle integrity through MEK1/ERK1/2 activity.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microtubule-system organizes the cytoplasm during interphase and segregates condensed chromosomes during mitosis. Four unrelated conserved proteins, XMAP215/Dis1/TOGp, MCAK, MAP4 and Op18/stathmin, have all been implicated as predominant regulators of tubulin monomer-polymer partitioning in animal cells. However, while studies employing the Xenopus egg extract model system indicate that the partitioning is largely governed by the counteractive activities of XMAP215 and MCAK, studies of human cell lines indicate that MAP4 and Op18 are the predominant regulators of the interphase microtubule-array. Here, we review functional interplay of these proteins during interphase and mitosis in various cell model systems. We also review the evidence that MAP4 and Op18 have interphase-specific, counteractive and phosphorylation-inactivated activities that govern tubulin subunit partitioning in many mammalian cell types. Finally, we discuss evidence indicating that partitioning regulation by MAP4 and Op18 may be of significance to establish cell polarity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.