Evidence map›Paper›PMID 19584941›Full record

ArticleInterdisciplinary perspectives on infectious diseases2009

Rapid Diagnosis of Intestinal Parasitic Protozoa, with a Focus on Entamoeba histolytica.

Anjana Singh, Eric Houpt, William A Petri

Open access · goldAbstract read
In one paragraph

Article in Interdisciplinary perspectives on infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Prevalence ofArchives of Razi Institute · 2022
    Article
  6. Article
  7. Molecular Identification and Prevalence ofPolish journal of microbiology · 2020
    Article
  8. Outbreak of intestinal amoebiasis among men who have sex with men, Barcelona (Spain), October 2016 and January 2017.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2017
    Article
  9. Article
  10. Article
  11. Parasitic colitis.Clinics in colon and rectal surgery · 2015
    Review
  12. Article
  13. Article
  14. Article
  15. Amebic liver abscess diagnosed by polymerase chain reaction in 14 returning travelers.The American journal of tropical medicine and hygiene · 2012
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Cardiac involvement with parasitic infections.Clinical microbiology reviews · 2010
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Anjana SinghUniversity of Virginia, Charlottesville, P.O. Box 801340, VA 22908-1340, USA.
Eric Houpt
William A Petri
Tribhuvan University · NPUniversity of Virginia · USUniversity of Virginia Health System · US

Funding

FIELD STUDIES OF IMMUNITY TO AMEBIASIS IN BANGLADESHR01AI043596 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CAROL A GILCHRIST, William A Petri · 1998 to 2026
$7.7M
UVA Digestive Health Research CenterP30DK067629 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COMINELLI, FABIO · 2004 to 2008
$5.6M
NIAID NIH HHS R01 AI043596NIDDK NIH HHS P30 DK067629
6 · The paper itself

Abstract

Entamoeba histolytica is an invasive intestinal pathogenic parasitic protozoan that causes amebiasis. It must be distinguished from Entamoeba dispar and E. moshkovskii, nonpathogenic commensal parasites of the human gut lumen that are morphologically identical to E. histolytica. Detection of specific E. histolytica antigens in stools is a fast, sensitive technique that should be considered as the method of choice. Stool real-time PCR is a highly sensitive and specific technique but its high cost make it unsuitable for use in endemic areas where there are economic constraints. Serology is an important component of the diagnosis of intestinal and especially extraintestinal amebiasis as it is a sensitive test that complements the detection of the parasite antigens or DNA. Circulating Gal/GalNac lectin antigens can be detected in the serum of patients with untreated amoebic liver abscess. On the horizon are multiplex real-time PCR assays which permit the identification of multiple enteropathogens with high sensitivity and specificity.

Identifiers

PMID19584941
PMCPMC2703877
OpenAlexW2108335589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.