ArticleEuropean journal of human genetics : EJHG2010
Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany.
Article in European journal of human genetics : EJHG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
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- CUBN is a gene locus for albuminuria.Journal of the American Society of Nephrology : JASN · 2011Pooled it
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- Protective Association of Single Nucleotide Polymorphisms rs1861868-FTO and rs7975232-VDR and Obesity in Saudi Females.International journal of general medicine · 2020Article
- Metabolic effects of genetic variation in the human REPIN1 gene.International journal of obesity (2005) · 2019Article
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- Complex Relationship between Obesity and the Fat Mass and Obesity Locus.International journal of biological sciences · 2017Review
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- Association of metabolic parameters and rs726344 in FNDC5 with serum irisin concentrations.International journal of obesity (2005) · 2016Article
- Genetic variants in AKR1B10 associate with human eating behavior.BMC genetics · 2015Article
- Role of genetic variants in ADIPOQ in human eating behavior.Genes & nutrition · 2015Article
- Signatures of natural selection at the FTO (fat mass and obesity associated) locus in human populations.PloS one · 2015Article
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19 authors at 6 institutions in 3 countries.
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Abstract
The association between common variants in the FTO gene with weight, adiposity and body mass index (BMI) has now been widely replicated. Although the causal variant has yet to be identified, it most likely maps within a 47 kb region of intron 1 of FTO. We performed a genome-wide association study in the Sorbian population and evaluated the relationships between FTO variants and BMI and fat mass in this isolate of Slavonic origin resident in Germany. In a sample of 948 Sorbs, we could replicate the earlier reported associations of intron 1 SNPs with BMI (eg, P-value=0.003, beta=0.02 for rs8050136). However, using genome-wide association data, we also detected a second independent signal mapping to a region in intron 2/3 about 40-60 kb away from the originally reported SNPs (eg, for rs17818902 association with BMI P-value=0.0006, beta=-0.03 and with fat mass P-value=0.0018, beta=-0.079). Both signals remain independently associated in the conditioned analyses. In conclusion, we extend the evidence that FTO variants are associated with BMI by putatively identifying a second susceptibility allele independent of that described earlier. Although further statistical analysis of these findings is hampered by the finite size of the Sorbian isolate, these findings should encourage other groups to seek alternative susceptibility variants within FTO (and other established susceptibility loci) using the opportunities afforded by analyses in populations with divergent mutational and/or demographic histories.
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