ArticleEuropean journal of human genetics : EJHG2010
Legacy of mutiny on the Bounty: founder effect and admixture on Norfolk Island.
Article in European journal of human genetics : EJHG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Evidence of inbreeding depression on human height.PLoS genetics · 2012Pooled it
- AnGenes · 2026Article
- Exploring the Functional Basis of Epigenetic Aging in Relation to Body Fat Phenotypes in the Norfolk Island Cohort.Current issues in molecular biology · 2023Article
- Genetic Characterization of Blood Group Antigens for Polynesian Heritage Norfolk Island Residents.Genes · 2023Article
- Pedigree derived mutation rate across the entire mitochondrial genome of the Norfolk Island population.Scientific reports · 2022Article
- Multi-phenotype genome-wide association studies of the Norfolk Island isolate implicate pleiotropic loci involved in chronic kidney disease.Scientific reports · 2021Article
- Genetic disease risks can be misestimated across global populations.Genome biology · 2018Article
- Gene-centric analysis implicates nuclear encoded mitochondrial protein gene variants in migraine susceptibility.Molecular genetics & genomic medicine · 2017Article
- Genome-wide linkage and association analysis of primary open-angle glaucoma endophenotypes in the Norfolk Island isolate.Molecular vision · 2017Article
- Serum bilirubin concentration is modified by UGT1A1 haplotypes and influences risk of type-2 diabetes in the Norfolk Island genetic isolate.BMC genetics · 2015Article
- A Phenomic Scan of the Norfolk Island Genetic Isolate Identifies a Major Pleiotropic Effect Locus Associated with Metabolic and Renal Disorder Markers.PLoS genetics · 2015Article
- Article
- 'Mutiny on the Bounty': the genetic history of Norfolk Island reveals extreme gender-biased admixture.Investigative genetics · 2015Article
- Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants.Nature communications · 2014Article
- Mapping eQTLs in the Norfolk Island genetic isolate identifies candidate genes for CVD risk traits.American journal of human genetics · 2013Article
- A genome-wide analysis of 'Bounty' descendants implicates several novel variants in migraine susceptibility.Neurogenetics · 2012Article
- Heritability and genome-wide linkage analysis of migraine in the genetic isolate of Norfolk Island.Gene · 2012Article
- Article
- Variants in the human potassium channel gene (KCNN3) are associated with migraine in a high risk genetic isolate.The journal of headache and pain · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The population of Norfolk Island, located off the eastern coast of Australia, possesses an unusual and fascinating history. Most present-day islanders are related to a small number of the 'Bounty' mutineer founders. These founders consisted of Caucasian males and Polynesian females and led to an admixed present-day population. By examining a single large pedigree of 5742 individuals, spanning >200 years, we analyzed the influence of admixture and founder effect on various cardiovascular disease (CVD)-related traits. On account of the relative isolation of the population, on average one-third of the genomes of present-day islanders (single large pedigree individuals) is derived from 17 initial founders. The proportion of Polynesian ancestry in the present-day individuals was found to significantly influence total triglycerides, body mass index, systolic blood pressure and diastolic blood pressure. For various cholesterol traits, the influence of ancestry was less marked but overall the direction of effect for all CVD-related traits was consistent with Polynesian ancestry conferring greater CVD risk. Marker-derived homozygosity was computed and agreed with measures of inbreeding derived from pedigree information. Founder effect (inbreeding and marker-derived homozygosity) significantly influenced height. In conclusion, both founder effect and extreme admixture have substantially influenced the genetic architecture of a variety of CVD-related traits in this population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.