Trial reportEuropean journal of clinical nutrition2009
Bioavailability of alpha-linolenic acid from flaxseed diets as a function of the age of the subject.
Trial report in European journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 89 citations in OpenAlex.
- Trial
- Identification of Cyclopropane Fatty Acids in Human Plasma after Controlled Dietary Intake of Specific Foods.Nutrients · 2020Trial
- The effect of flaxseed dose on circulating concentrations of alpha-linolenic acid and secoisolariciresinol diglucoside derived enterolignans in young, healthy adults.European journal of nutrition · 2016Trial
- Consumption of echium oil increases EPA and DPA in blood fractions more efficiently compared to linseed oil in humans.Lipids in health and disease · 2016Trial
- Anti-Oxidant and Anti-Cancer Properties of Flaxseed.International journal of molecular sciences · 2025Review
- Protective Effect of Alpha-Linolenic Acid on Human Oral Squamous Cell Carcinoma Metastasis and Apoptotic Cell Death.Nutrients · 2023Article
- Physiological and Pathological Considerations for the Use of Flaxseed as a Therapeutic Dietary Strategy.Reviews in cardiovascular medicine · 2023Review
- Article
- Effect of essential fatty acid blend on circadian variations of ambulatory blood pressure in patients with essential hypertension and coronary artery disease risk markers.Journal of human hypertension · 2022Article
- Effect of dietary flaxseed oil on the prognosis of acute anterior cruciate ligament rupture: a randomized placebo-controlled trial.American journal of translational research · 2022Article
- Enrichment of Broiler Chickens' Meat with Dietary Linseed Oil and Lysine Mixtures: Influence on Nutritional Value, Carcass Characteristics and Oxidative Stress Biomarkers.Foods (Basel, Switzerland) · 2021Article
- Single-Dose SDA-Rich Echium Oil Increases Plasma EPA, DPAn3, and DHA Concentrations.Nutrients · 2019Article
- Therapeutic effect of flax-based diets on fatty liver in aged laying hens.Poultry science · 2016Article
- Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition.Oncotarget · 2015Review
- A review of the effect of omega-3 polyunsaturated fatty acids on blood triacylglycerol levels in normolipidemic and borderline hyperlipidemic individuals.Lipids in health and disease · 2015Review
- Review
- The cardiovascular effects of flaxseed and its omega-3 fatty acid, alpha-linolenic acid.The Canadian journal of cardiology · 2010Review
- The cardiac and haemostatic effects of dietary hempseed.Nutrition & metabolism · 2010Article
- Relationship between Fecal Content of Fatty Acids and Cyclooxygenase mRNA Expression and Fatty Acid Composition in Duodenal Biopsies, Serum Lipoproteins, and Dietary Fat in Colectomized Familial Adenomatous Polyposis Patients.Journal of nutrition and metabolism · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDietary flaxseed may have beneficial cardiovascular effects. An aged population has a higher incidence of cardiovascular disease, but they may react differently to flaxseed in the diet.
objectiveTo investigate the response, over a period of 4 weeks, of subjects aged 18-29 or 45-69 years to a diet containing the same amount of alpha-linolenic acid (ALA) (6 g) introduced in the form of ground flaxseed (30 g) or flaxseed oil.
resultsAll subjects who received flaxseed oil showed a significant increase in plasma ALA and eicosapentaenoic acid (EPA) concentrations over the course of this study. Subjects who received ground flaxseed in the 18-29-year-old group showed a statistically significant increase in their plasma ALA levels, and although there was a trend in the same direction for the 45-69-year-old subjects, this did not achieve statistical significance. The diets induced no major changes in platelet aggregation, plasma total cholesterol, low-density lipoprotein or high-density lipoprotein cholesterol levels in any of the groups. Younger subjects showed a decrease in triglyceride (TG) values compared with older subjects. There were no significant side effects that caused compliancy issues.
conclusionSubject age does not seem to be a major determining factor in influencing ALA absorption from a flaxseed-supplemented diet nor in the metabolism of ALA to EPA in the groups fed flaxseed oil. Concerns about side effects in older subjects administered a higher fiber load in a flaxseed-supplemented diet are not justified. However, younger but not older subjects showed a beneficial decrease in circulating TGs due to flaxseed supplementation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.