ArticleObesity (Silver Spring, Md.)2009
Admixture mapping of quantitative trait loci for BMI in African Americans: evidence for loci on chromosomes 3q, 5q, and 15q.
Article in Obesity (Silver Spring, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes.International journal of obesity (2005) · 2021Pooled it
- Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe).Human molecular genetics · 2012Pooled it
- Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium.Human molecular genetics · 2011Pooled it
- Joint multi-ancestry and admixed GWAS reveals the complex genetics behind human cranial vault shape.Nature communications · 2023Review
- Admixture mapping of anthropometric traits in the Black Women's Health Study: evidence of a shared African ancestry component with birth weight and type 2 diabetes.Journal of human genetics · 2022Article
- Identifying Rare Variant Associations in Admixed Populations.Scientific reports · 2019Article
- Local Ancestry and Clinical Cardiovascular Events Among African Americans From the Atherosclerosis Risk in Communities Study.Journal of the American Heart Association · 2017Article
- Variants for HDL-C, LDL-C, and triglycerides identified from admixture mapping and fine-mapping analysis in African American families.Circulation. Cardiovascular genetics · 2015Article
- Extensive copy number variations in admixed Indian population of African ancestry: potential involvement in adaptation.Genome biology and evolution · 2014Article
- Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations.Genome medicine · 2014Article
- Genetic admixture and obesity: recent perspectives and future applications.Human heredity · 2013Review
- Variants in CXADR and F2RL1 are associated with blood pressure and obesity in African-Americans in regions identified through admixture mapping.Journal of hypertension · 2012Article
- Association of serum lipid components and obesity with genetic ancestry in an admixed population of elderly women.Genetics and molecular biology · 2012Article
- Power comparison of admixture mapping and direct association analysis in genome-wide association studies.Genetic epidemiology · 2012Article
- Relationship between adiposity and admixture in African-American and Hispanic-American women.International journal of obesity (2005) · 2012Article
- The analysis of ethnic mixtures.Methods in molecular biology (Clifton, N.J.) · 2012Article
- The admixture structure and genetic variation of the archipelago of Cape Verde and its implications for admixture mapping studies.PloS one · 2012Article
- Recent admixture in an Indian population of African ancestry.American journal of human genetics · 2011Article
- Admixture mapping to identify spontaneous preterm birth susceptibility loci in African Americans.Obstetrics and gynecology · 2011Article
- A genome-wide admixture scan for ancestry-linked genes predisposing to sarcoidosis in African-Americans.Genes and immunity · 2011Article
Corrections and comments
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Authors and funding
11 authors at 9 institutions in 2 countries.
Funding
Abstract
Obesity is a heritable trait and a major risk factor for highly prevalent common diseases such as hypertension and type 2 diabetes. Previously we showed that BMI was positively correlated with African ancestry among the African Americans (AAs) in the US National Heart, Lung, and Blood Institute's Family Blood Pressure Program (FBPP). In a set of 1,344 unrelated AAs, using Individual Ancestry (IA) estimates at 284 marker locations across the genome, we now present a quantitative admixture mapping analysis of BMI. We used a set of unrelated individuals from Nigeria to represent the African ancestral population and the European American (EA) in the FBPP as the European ancestral population. The analysis was based on a common set of 284 microsatellite markers genotyped in all three groups. We considered the quantitative trait, BMI, as the response variable in a regression analysis with the marker location specific excess European ancestry as the explanatory variable. After suitably adjusting for different covariates such as sex, age, and network, we found strong evidence for a positive association with European ancestry at chromosome locations 3q29 and 5q14 and a negative association on chromosome 15q26. To our knowledge, this is the largest quantitative admixture mapping effort in terms of sample size and marker locus involvement for the trait. These results suggest that these regions may harbor genes influencing BMI in the AA population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.