ReviewMolecular therapy : the journal of the American Society of Gene Therapy2009
Mesenchymal stromal cells as supportive cells for hepatocytes.
Review in Molecular therapy : the journal of the American Society of Gene Therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Global research trends in liver regeneration and immunomodulation: A perspective from bibliometric analysis.Human vaccines & immunotherapeutics · 2025Article
- The Crosstalk between Mesenchymal Stromal/Stem Cells and Hepatocytes in Homeostasis and under Stress.International journal of molecular sciences · 2023Review
- Surface modification of decellularized bovine carotid arteries with human vascular cells significantly reduces their thrombogenicity.Journal of biological engineering · 2021Article
- Hepatocyte and mesenchymal stem cell co-transplantation in rats with acute liver failure.Korean journal of transplantation · 2020Article
- Amniotic mesenchymal stem cells derived hepatocyte-like cells attenuated liver fibrosis more efficiently by mixed-cell transplantation.International journal of physiology, pathophysiology and pharmacology · 2020Article
- Stem Cell-Based Therapies for Liver Diseases: An Overview and Update.Tissue engineering and regenerative medicine · 2019Review
- Establishment of human hair follicle mesenchymal stem cells with overexpressed human hepatocyte growth factor.Iranian journal of basic medical sciences · 2017Article
- Article
- Effect of Yiguanjian decoction on cell differentiation and proliferation in CCl₄-treated mice.World journal of gastroenterology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocytes and hematopoietic stem cells (HSCs) appear to share many of the same requirements for their survival, functionality, and proliferation. This may be due to a shared location during fetal development. Moreover, hepatocytes and HSCs are unable to function, or even survive, without stromal cell support. Bone marrow-derived mesenchymal stromal cells (MSCs) support the proliferation and functionality, not only of HSCs, but also of hepatocytes. Although knowledge of the mechanisms underlying HSCs' support is far more advanced than for hepatocytes, data suggest that many agents important for HSCs also maintain the normal hepatocyte phenotype in vitro. Thus, it is possible that new techniques for the maintenance and expansion of HSCs may also be useful for hepatocytes. Bone marrow-derived MSCs are easily cultured and expanded in vitro, and some data suggest that they are immunoregulatory as well as relatively nonimmunogenic. These observations suggest that allogeneic MSCs may be useful not only in supporting hepatocyte growth and proliferation but also in modulating immune responses such as stellate cell activation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.