ArticleBehavioural pharmacology2009
Effects of environmental enrichment on sensitivity to cocaine in female rats: importance of control rates of behavior.
Article in Behavioural pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Social isolation at adolescence: a systematic review on behaviour related to cocaine, amphetamine and nicotine use in rats and mice.Psychopharmacology · 2021Pooled it
- Environmental enrichment promotes adaptive responding during tests of behavioral regulation in male heterogeneous stock rats.Scientific reports · 2024Article
- A bibliometric analysis of studies on environmental enrichment spanning 1967-2024: patterns and trends over the years.Frontiers in behavioral neuroscience · 2024Article
- Neurobehavioral effects of environmental enrichment and drug abuse vulnerability: An updated review.Pharmacology, biochemistry, and behavior · 2022Review
- Early environmental enrichment and impoverishment differentially affect addiction-related behavioral traits, cocaine-taking, and dopamine DPsychopharmacology · 2021Article
- Sex differences in the effects of a combined behavioral and pharmacological treatment strategy for cocaine relapse prevention in an animal model of cue exposure therapy.Behavioural brain research · 2020Article
- Environmental enrichment and drug value: a behavioral economic analysis in male rats.Addiction biology · 2019Article
- Effects of environmental enrichment on d-amphetamine self-administration following nicotine exposure.Experimental and clinical psychopharmacology · 2017Article
- Differential housing and novelty response: Protection and risk from locomotor sensitization.Pharmacology, biochemistry, and behavior · 2017Article
- Pharmacological manipulation of glucocorticoid receptors differentially affects cocaine self-administration in environmentally enriched and isolated rats.Behavioural brain research · 2015Article
- Inoculation stress hypothesis of environmental enrichment.Neuroscience and biobehavioral reviews · 2015Review
- Environmental enrichment reduces methamphetamine cue-induced reinstatement but does not alter methamphetamine reward or VMAT2 function.Behavioural brain research · 2014Article
- The effects of social learning on the acquisition of cocaine self-administration.Drug and alcohol dependence · 2014Article
- Effects of cocaine combined with a social cue on conditioned place preference and nucleus accumbens monoamines after isolation rearing in rats.Psychopharmacology · 2014Article
- Chronic wheel running reduces maladaptive patterns of methamphetamine intake: regulation by attenuation of methamphetamine-induced neuronal nitric oxide synthase.Brain structure & function · 2014Article
- Individual differences and social influences on the neurobehavioral pharmacology of abused drugs.Pharmacological reviews · 2013Review
- Article
- Environmental enrichment during development decreases intravenous self-administration of methylphenidate at low unit doses in rats.Behavioural pharmacology · 2012Article
- Sex differences in the effects of social and physical environment on novelty-induced exploratory behavior and cocaine-stimulated locomotor activity in adolescent rats.Behavioural brain research · 2012Article
- Access to a running wheel decreases cocaine-primed and cue-induced reinstatement in male and female rats.Drug and alcohol dependence · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Environmental enrichment produces functional changes in mesolimbic dopamine transmission and alters sensitivity to psychomotor stimulants. These manipulations also alter the control rate of many behaviors that are sensitive to stimulant administration, which can make comparison of drug effects between isolated and enriched subjects difficult. The purpose of this study was to examine the effects of environmental enrichment on control rates of behavior and on sensitivity to cocaine in tests of locomotor activity, drug self-administration, conditioned place preference, and toxicity. In the locomotor activity test, isolated rats exhibited greater activity after the administration of cocaine, but also had higher control rates of activity. When locomotor activity was expressed as a percentage of saline control values, enriched rats exhibited a greater increase relative to their own control than isolated rats. In the drug self-administration procedure, isolated rats had higher breakpoints on a progressive-ratio schedule of reinforcement when responding was maintained by cocaine; however, isolated rats also had higher breakpoints in saline substitution tests and higher rates of inactive lever responding. When the self-administration data were expressed as a percentage of these control values, enriched rats exhibited a greater increase in responding relative to their own control rates than isolated rats. No differences were observed between isolated and enriched rats under control conditions in the place preference and toxicity studies. In both of these procedures, enriched rats were more sensitive than isolated rats to all the doses of cocaine tested. These data emphasize the importance of considering control rates of behavior in studies examining environmental enrichment and drug sensitivity, and suggest that environmental enrichment increases sensitivity to cocaine across a range of dependent measures when differences in control rates of behavior are taken into account.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.