ArticleAnnals of Saudi medicine
Experience with oral mexiletine in primary erythromelalgia in children.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Primary erythromelalgia mainly manifested by hypertensive crisis: A case report and literature review.Frontiers in pediatrics · 2022Review
- Acute monophasic erythromelalgia pain in five children diagnosed as small-fiber neuropathy.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2020Article
- Current pain management strategies for patients with erythromelalgia: a critical review.Journal of pain research · 2018Review
- Primary erythromelalgia: a review.Orphanet journal of rare diseases · 2015Review
- Mutational consequences of aberrant ion channels in neurological disorders.The Journal of membrane biology · 2014Review
- An Egyptian child with erythromelalgia responding to a new line of treatment: a case report and review of the literature.Journal of medical case reports · 2014Article
- Neurological perspectives on voltage-gated sodium channels.Brain : a journal of neurology · 2012Review
- Erythromelalgia: an uncommon presentation precipitated by aspirin withdrawal.Case reports in medicine · 2012Article
- Sodium channelopathies and pain.Pflugers Archiv : European journal of physiology · 2010Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary erythromelalgia is characterized by burning pain, redness, and warmth in the extremities. We present two cases of primary erythromelalgia both of whom presented with a history of several months of severe burning pain in both hands and feet. Both patients had received multiple pain medications with no improvement in symptoms. Pain was relieved by putting affected parts in ice cold water, which resulted in immersion injury of the affected parts. Both patients stopped taking part in school and social activities. We tried oral mexiletine, a class Ib antiarrythmic agent, in view of its reported role in various chronic painful conditions. Dramatic improvement was observed with its use. Both patients improved after several weeks of use, and there were fewer soaking episodes. We observed no adverse effects with mexilitine therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.