ArticleProceedings of the National Academy of Sciences of the United States of America2009
Long-term sensory deprivation selectively rearranges functional inhibitory circuits in mouse barrel cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Time Window of the Critical Period for Neuroplasticity in S1, V1, and A1 Sensory Areas of Small Rodents: A Systematic Review.Frontiers in neuroanatomy · 2022Pooled it
- The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities.IBRO neuroscience reports · 2022Review
- Impact of somatostatin interneurons on interactions between barrels in plasticity induced by whisker deprivation.Scientific reports · 2022Article
- Dexmedetomidine - Commonly Used in Functional Imaging Studies - Increases Susceptibility to Seizures in Rats But Not in Wild Type Mice.Frontiers in neuroscience · 2020Article
- Article
- Conductive Hearing Loss Has Long-Lasting Structural and Molecular Effects on Presynaptic and Postsynaptic Structures of Auditory Nerve Synapses in the Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Fmr1 KO and fenobam treatment differentially impact distinct synapse populations of mouse neocortex.Neuron · 2014Article
- Two functional inhibitory circuits are comprised of a heterogeneous population of fast-spiking cortical interneurons.Neuroscience · 2014Article
- Synaptic molecular imaging in spared and deprived columns of mouse barrel cortex with array tomography.Scientific data · 2014Article
- Increases in the numerical density of GAT-1 positive puncta in the barrel cortex of adult mice after fear conditioning.PloS one · 2014Article
- Functional signature of recovering cortex: dissociation of local field potentials and spiking activity in somatosensory cortices of spinal cord injured monkeys.Experimental neurology · 2013Article
- Environmental enrichment causes a global potentiation of neuronal responses across stimulus complexity and lamina of sensory cortex.Frontiers in cellular neuroscience · 2013Article
- Deep molecular diversity of mammalian synapses: why it matters and how to measure it.Nature reviews. Neuroscience · 2012Review
- α4* Nicotinic acetylcholine receptors modulate experience-based cortical depression in the adult mouse somatosensory cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Basic Concepts in Understanding Recovery of Function in Vestibular Reflex Networks during Vestibular Compensation.Frontiers in neurology · 2012Article
- Enriched and deprived sensory experience induces structural changes and rewires connectivity during the postnatal development of the brain.Neural plasticity · 2012Review
- Plasticity of spontaneous excitatory and inhibitory synaptic activity in morphologically defined vestibular nuclei neurons during early vestibular compensation.Journal of neurophysiology · 2012Article
- Fragile X syndrome: the GABAergic system and circuit dysfunction.Developmental neuroscience · 2011Review
- Assortment of GABAergic plasticity in the cortical interneuron melting pot.Neural plasticity · 2011Review
- Distinct α subunit variations of the hypothalamic GABAA receptor triplets (αβγ) are linked to hibernating state in hamsters.BMC neuroscience · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Long-term whisker removal alters the balance of excitation and inhibition in rodent barrel cortex, yet little is known about the contributions of individual cells and synapses in this process. We studied synaptic inhibition in four major types of neurons in live tangential slices that isolate layer 4 in the posteromedial barrel subfield. Voltage-clamp recordings of layer 4 neurons reveal that fast decay of synaptic inhibition requires alpha1-containing GABA(A) receptors. After 7 weeks of deprivation, we found that GABA(A)-receptor-mediated inhibitory postsynaptic currents (IPSCs) in the inhibitory low-threshold-spiking (LTS) cell recorded in deprived barrels exhibited faster decay kinetics and larger amplitudes in whisker-deprived barrels than those in nondeprived barrels in age-matched controls. This was not observed in other cell types. Additionally, IPSCs recorded in LTS cells from deprived barrels show a marked increase in zolpidem sensitivity. To determine if the faster IPSC decay in LTS cells from deprived barrels indicates an increase in alpha1 subunit functionality, we deprived alpha1(H101R) mutant mice with zolpidem-insensitive alpha1-containing GABA(A) receptors. In these mice and matched wild-type controls, IPSC decay kinetics in LTS cells were faster after whisker removal; however, the deprivation-induced sensitivity to zolpidem was reduced in alpha1(H101R) mice. These data illustrate a change of synaptic inhibition in LTS cells via an increase in alpha1-subunit-mediated function. Because alpha1 subunits are commonly associated with circuit-specific plasticity in sensory cortex, this switch in LTS cell synaptic inhibition may signal necessary circuit changes required for plastic adjustments in sensory-deprived cortex.
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Registered trials
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