Trial reportThe Journal of clinical endocrinology and metabolism2009
Antiresorptive effects of phytoestrogen supplements compared with estradiol or risedronate in postmenopausal women using (41)Ca methodology.
Trial report in The Journal of clinical endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Oral vs. Non-oral Contraceptive Therapy on Bone Turnover Using 41Ca Methodology
Berries and Bones: The Effect of Polyphenolic Metabolites From Blueberries on Bone Turnover
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Prevention of bone resorption by intake of phytoestrogens in postmenopausal women: a meta-analysis.Age (Dordrecht, Netherlands) · 2011Pooled it
- Impact of equol-producing capacity and soy-isoflavone profiles of supplements on bone calcium retention in postmenopausal women: a randomized crossover trial.The American journal of clinical nutrition · 2015Trial
- Red clover isoflavones enriched with formononetin lower serum LDL cholesterol-a randomized, double-blind, placebo-controlled study.European journal of clinical nutrition · 2015Trial
- Article
- Article
- Nutraceuticals in osteoporosis prevention.Frontiers in nutrition · 2024Review
- Perspectives on the application of CONSORT guidelines to randomised controlled trials in nutrition.European journal of nutrition · 2023Article
- The health effects of soy: A reference guide for health professionals.Frontiers in nutrition · 2022Review
- Designing, Conducting, and Documenting Human Nutrition Plant-Derived Intervention Trials.Frontiers in nutrition · 2021Article
- Effects of Dietary Phytoestrogens on Hormones throughout a Human Lifespan: A Review.Nutrients · 2020Review
- Effect of whole soy and isoflavones daidzein on bone turnover and inflammatory markers: a 6-month double-blind, randomized controlled trial in Chinese postmenopausal women who are equol producers.Therapeutic advances in endocrinology and metabolism · 2020Article
- Exercise prevents high fat diet-induced bone loss, marrow adiposity and dysbiosis in male mice.Bone · 2019Article
- Calcium-41: a technology for monitoring changes in bone mineral.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Review
- Preventive effects of kudzu root on bone loss and cartilage degradation in ovariectomized rats [corrected].American journal of translational research · 2017Article
- A Bayesian approach to an interlaboratory comparison.Chemometrics and intelligent laboratory systems : an international journal sponsored by the Chemometrics Society · 2015Article
- Validation of urinary calcium isotope excretion from bone for screening anabolic therapies for osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Plum and soy aglycon extracts superior at increasing bone calcium retention in ovariectomized Sprague Dawley rats.Journal of agricultural and food chemistry · 2014Article
- Fecal bacterial community changes associated with isoflavone metabolites in postmenopausal women after soy bar consumption.PloS one · 2014Article
- Ultra-trace analysis ofNuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms · 2013Article
- Calcium isolation from large-volume human urine samples for 41Ca analysis by accelerator mass spectrometry.Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
introductionReduction of ovarian estrogen secretion at menopause increases net bone resorption and leads to bone loss. Isoflavones have been reported to protect bone from estrogen deficiency, but their modest effects on bone resorption have been difficult to measure with traditional analytical methods.
methodsIn this randomized-order, crossover, blinded trial in 11 healthy postmenopausal women, we compared four commercial sources of isoflavones from soy cotyledon, soy germ, kudzu, and red clover and a positive control of oral 1 mg estradiol combined with 2.5 mg medroxyprogesterone or 5 mg/d oral risedronate (Actonel) for their antiresorptive effects on bone using novel (41)Ca methodology.
resultsRisedronate and estrogen plus progesterone decreased net bone resorption measured by urinary (41)Ca by 22 and 24%, respectively (P < 0.0001). Despite serum isoflavone profiles indicating bioavailability of the phytoestrogens, only soy isoflavones from the cotyledon and germ significantly decreased net bone resorption by 9% (P = 0.0002) and 5% (P = 0.03), respectively. Calcium absorption and biochemical markers of bone turnover were not influenced by interventions.
conclusionsDietary supplements containing genistein-like isoflavones demonstrated a significant but modest ability to suppress net bone resorption in postmenopausal women at the doses supplied in this study over a 50-d intervention period.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.