ArticleFamily practice2009
High medical co-morbidity and family history of dementia is associated with lower cognitive function in older patients.
Article in Family practice, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Combining modifiable risk factors and risk of dementia: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- Unsupervised Online Paired Associates Learning Task from the Cambridge Neuropsychological Test Automated Battery (CANTAB®) in the Brain Health Registry.The journal of prevention of Alzheimer's disease · 2024Article
- Executive function performance in middle-aged adults.Dementia & neuropsychologia · 2023Article
- Predictors of Residential Care Admission in Community-Dwelling Older People With Dementia.Journal of the American Medical Directors Association · 2020Observational
- Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry.Alzheimer's & dementia (Amsterdam, Netherlands) · 2018Article
- Serum Levels of ApoA1 and ApoA2 Are Associated with Cognitive Status in Older Men.BioMed research international · 2015Article
- Genetic Risk Score Predicts Late-Life Cognitive Impairment.Journal of aging research · 2015Article
- Association between Cognitive Decline in Older Adults and Use of Primary Care Physician Services in Pennsylvania.Journal of primary care & community health · 2012Article
- Determining the association of medical co-morbidity with subjective and objective cognitive performance in an inner city memory disorders clinic: a retrospective chart review.BMC geriatrics · 2010Article
- Association of allostatic load with all-cause and cause-specific dementia: A prospective cohort study.Alzheimer's & dementia (New York, N. Y.)Article
- Terms and Measures of Cognitive Health Associated With Dementia and Alzheimer's Disease: A Scoping Review.Research on agingArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundRisk factors for cognitive decline in ageing are multifactorial, including medical co-morbidities and familial genetic risk.
objectivesTo assess the effect of medical co-morbidity and family history of dementia on cognitive performance in older outpatients of family practitioners.
methodsAnalysis of 535 outpatients from 11 practices aged 65 and older, without a diagnosis of dementia. Information on medical co-morbidities, family history of dementia and cognitive test data were obtained.
resultsPatients were classified into high or low medical co-morbidities (<7 versus >8) and positive or negative family history of dementia. After controlling for age, education, gender and depression, global cognitive test scores, as well as memory, executive function, spatial ability and attention were significantly lower for persons having a high number of medical co-morbidities. Cognitive test scores were not significantly different for persons with or without a family history of dementia. A significant interaction between medical co-morbidities and family history of dementia was observed for the global cognitive score, executive function and spatial ability. Those persons with a high number of medical co-morbidities and positive family history of dementia had the lowest performance. Separate regression analysis assessing individual disease risk factors (e.g. hypertension and diabetes) did not find any relationship between specific medical variables and cognitive test scores for any of the subgroups.
conclusionsA high number of medical co-morbidities in addition to a reported family history of dementia are particularly detrimental to cognitive performance in elderly non-demented family practice patients.
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