Trial reportTrials2009
Intravenous fluid restriction after major abdominal surgery: a randomized blinded clinical trial.
Trial report in Trials, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Perioperative Fluid Restriction in Abdominal Surgery: A Systematic Review and Meta-analysis.World journal of surgery · 2019Pooled it
- Systematic Review and Meta-analysis of Restrictive Perioperative Fluid Management in Pancreaticoduodenectomy.World journal of surgery · 2018Pooled it
- Perioperative fluid restriction in major abdominal surgery: systematic review and meta-analysis of randomized, clinical trials.World journal of surgery · 2013Pooled it
- Restrictive versus liberal fluid therapy in major abdominal surgery (RELIEF): rationale and design for a multicentre randomised trial.BMJ open · 2017Trial
- Prospective Randomized Controlled Trial of Liberal Vs Restricted Perioperative Fluid Management in Patients Undergoing Pancreatectomy.Annals of surgery · 2016Trial
- Necessity of subcutaneous suction drains in ileostomy reversal (DRASTAR)-a randomized, controlled bi-centered trial.Langenbeck's archives of surgery · 2016Trial
- Intraoperative Fluid Restriction in Pancreatic Surgery: A Double Blinded Randomised Controlled Trial.PloS one · 2015Trial
- Randomized clinical trial of fluid and salt restriction compared with a controlled liberal regimen in elective gastrointestinal surgery.The British journal of surgery · 2013Trial
- Intraoperative hemodynamic management during pancreatoduodenectomy - an analysis of 525 patients.Langenbeck's archives of surgery · 2025Article
- Influence of awakening from general anesthesia on the distribution of glucose 2.5% with balanced electrolytes in adults.Frontiers in medicine · 2025Article
- Restrictive versus conventional ward fluid therapy in non-cardiac surgery patients and the effect on postoperative complications: a meta-analysis.Perioperative medicine (London, England) · 2023Review
- Review
- Diuretic response to Ringer's solution is normal shortly after awakening from general anaesthesia: a retrospective kinetic analysis.BJA open · 2022Article
- Impact of Intravenous Fluids and Enteral Nutrition on the Severity of Gastrointestinal Dysfunction: A Systematic Review and Meta-analysis.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2020Article
- Goal-directed therapy in intraoperative fluid and hemodynamic management.Journal of biomedical research · 2013Review
- Intraoperative fluid management and complications following pancreatectomy.Journal of surgical oncology · 2013Article
- [Intraoperative surgical and anesthesiological problems and the consequences for surgery].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2012Article
- Fluid overload at initiation of renal replacement therapy is associated with lack of renal recovery in patients with acute kidney injury.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2012Article
- Surgical intensive care unit - essential for good outcome in major abdominal surgery?Langenbeck's archives of surgery · 2011Review
- CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials.BMJ (Clinical research ed.) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntravenous (IV) fluid administration is an essential part of postoperative care. Some studies suggest that a restricted post-operative fluid regime reduces complications and postoperative hospital stay after surgery. We investigated the effects of postoperative fluid restriction in surgical patients undergoing major abdominal surgery.
methodsIn a blinded randomized trial, 62 patients (ASA I-III) undergoing elective major abdominal surgical procedures in a university hospital were allocated either to a restricted (1.5 L/24 h) or a standard postoperative IV fluid regime (2.5 L/24 h). Primary endpoint was length of postoperative hospital stay (PHS). Secondary endpoints included postoperative complications and time to restore gastric functions.
resultsAfter a 1-year inclusion period, an unplanned interim analysis was made because of many protocol violations due to patient deterioration. In the group with the restricted regime we found a significantly increased PHS (12.3 vs. 8.3 days; p = 0.049) and significantly more major complications: 12 in 30 (40%) vs. 5 in 32 (16%) patients (Absolute Risk Increase: 0.24 [95%CI: 0.03 to 0.46], i.e. a number needed to harm of 4 [95%CI: 2-33]). Therefore, the trial was stopped prematurely. Intention to treat analysis showed no differences in time to restore gastric functions between the groups.
conclusionRestricted postoperative IV fluid management, as performed in this trial, in patients undergoing major abdominal surgery appears harmful as it is accompanied by an increased risk of major postoperative complications and a prolonged postoperative hospital stay.
trial registrationCurrent Controlled Trials ISRCTN16719551.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.