ReviewJournal of clinical hypertension (Greenwich, Conn.)2009
Improving outcomes in hypertensive patients: focus on adherence and persistence with antihypertensive therapy.
Review in Journal of clinical hypertension (Greenwich, Conn.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Single-pill vs free-equivalent combination therapies for hypertension: a meta-analysis of health care costs and adherence.Journal of clinical hypertension (Greenwich, Conn.) · 2011Pooled it
- The association of depression with adherence to antihypertensive medications: a systematic review.Journal of hypertension · 2010Pooled it
- Differential treatment of hypertension by primary care providers and hypertension specialists in a barber-based intervention trial to control hypertension in Black men.The American journal of cardiology · 2013Trial
- Antihypertensive response to combination of olmesartan and amlodipine does not depend on method and time of drug administration.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2013Trial
- Effects of manidipine and its combination with an ACE inhibitor on insulin sensitivity and metabolic, inflammatory and prothrombotic markers in hypertensive patients with metabolic syndrome: the MARCADOR study.Clinical drug investigation · 2011Trial
- Overcoming Psychological Barriers to Treatment Adherence: The Case of Antihypertensive Medication.Cardiology clinics · 2026Review
- ADHD and adherence to antihypertensive medication treatment: a multinational cohort study.BMC medicine · 2026Article
- Use of Self-Measured Blood Pressure Monitoring to Improve Hypertension Equity.Current hypertension reports · 2022Review
- Determining the Prevalence of and the Factors Associated with Antihypertensive Medication Non-Adherence in the Gaza Strip.Korean journal of family medicine · 2021Article
- Importance of extracellular vesicles in hypertension.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Government-Expert Joint Intervention with Treatment Algorithm and Improved Hypertension Management and Reduced Stroke Mortality in a Primary-Care Setting.International journal of hypertension · 2021Article
- Health care utilisation and out-of-pocket expenditure associated with hypertension: an analysis of Australian adults from the 45 and Up Study.Journal of human hypertension · 2020Article
- Impact of number of medications and age on adherence to antihypertensive medications: A nationwide population-based study.Medicine · 2019Observational
- Iatrogenic hypertension: a bioinformatic analysis.The pharmacogenomics journal · 2019Article
- Using Values Affirmation to Reduce the Effects of Stereotype Threat on Hypertension Disparities: Protocol for the Multicenter Randomized Hypertension and Values (HYVALUE) Trial.JMIR research protocols · 2019Article
- Clinical outcomes in hypertensive patients treated with a single-pill fixed-dose combination of renin-angiotensin system inhibitor and thiazide diuretic.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Medication Adherence in Korean Hypertensive Patients.Korean journal of family medicine · 2018Article
- Medication compliance and clinical outcomes of fixed-dose combinations vs free combinations of an angiotensin II receptor blocker and a calcium channel blocker in hypertension treatment.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
- Persistence with antihypertensives in uncomplicated treatment-naïve very elderly patients: a nationwide population-based study.BMC cardiovascular disorders · 2017Article
- Systolic Blood Pressure and Biochemical Assessment of Adherence: A Cross-Sectional Analysis in the Emergency Department.Hypertension (Dallas, Tex. : 1979) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although effective control of blood pressure (BP) reduces the risk of cardiovascular events in patients with hypertension, BP control rates among treated patients in actual clinical practice are less than optimal. Although the costs of medicines and medical care (which are difficult to estimate both in clinical trials and general clinical practice) are important, medication-taking behavior--adherence and persistence with antihypertensive regimens--influences BP control rates. Many factors affect adherence and persistence with medications, including efficacy and tolerability of drugs prescribed, such that rates vary greatly among antihypertensive classes. In general, medications with fewer adverse effects (in registration trials or large outcomes studies) are associated with increased adherence and lower discontinuation rates. More widespread use of such agents, particularly those available in generic formulations or in low-cost formularies, may lead to better long-term BP control and fewer cardiovascular events.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.