ArticleThe Journal of infectious diseases2009
Gene transcript abundance profiles distinguish Kawasaki disease from adenovirus infection.
Article in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Neutrophil to Lymphocyte Ratio as a Biomarker for Predicting the Coronary Artery Abnormality in Kawasaki Disease: A Meta-Analysis.Disease markers · 2022Pooled it
- Evaluation of gene expression classification studies: factors associated with classification performance.PloS one · 2014Pooled it
- Gene expression profiles in febrile children with defined viral and bacterial infection.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Monocyte Single-Cell-Type Gene Expression Analysis Differentiates Kawasaki Disease From Viral Infection With High Specificity.Journal of cellular and molecular medicine · 2026Article
- HHV-6B detection and host gene expression implicate HHV-6B as pulmonary pathogen after hematopoietic cell transplant.Nature communications · 2024Article
- Calculating the fraction of Kawasaki disease potentially attributable to seasonal pathogens: a time series analysis.EClinicalMedicine · 2023Article
- Innate immune response analysis in COVID-19 and kawasaki disease reveals MIS-C predictors.Journal of the Formosan Medical Association = Taiwan yi zhi · 2022Article
- Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients.Nature communications · 2021Article
- Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management.Rheumatology international · 2021Review
- A Diagnostic Model for Kawasaki Disease Based on Immune Cell Characterization From Blood Samples.Frontiers in pediatrics · 2021Article
- Another compelling evidence suggesting infectious diseases as the cause of Kawasaki disease?Journal of the Chinese Medical Association : JCMA · 2020Article
- Kawasaki Disease: Global Burden and Genetic Background.Cardiology research · 2020Review
- Distinguishing Kawasaki Disease from Febrile Infectious Disease Using Gene Pair Signatures.BioMed research international · 2020Article
- Aetiological Significance of Infectious Stimuli in Kawasaki Disease.Frontiers in pediatrics · 2019Review
- Diagnosis of Kawasaki Disease Using a Minimal Whole-Blood Gene Expression Signature.JAMA pediatrics · 2018Article
- Is Kawasaki disease an infectious disorder?International journal of rheumatic diseases · 2018Review
- Whole blood transcriptional profiles as a prognostic tool in complete and incomplete Kawasaki Disease.PloS one · 2018Article
- How Should We Classify Kawasaki Disease?Frontiers in immunology · 2018Review
- Pediatric Kawasaki Disease and Adult Human Immunodeficiency Virus Kawasaki-Like Syndrome Are Likely the Same Malady.Open forum infectious diseases · 2016Article
- Robust classification of bacterial and viral infections via integrated host gene expression diagnostics.Science translational medicine · 2016Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAcute Kawasaki disease (KD) is difficult to distinguish from other illnesses that involve acute rash or fever, in part because the etiologic agent(s) and pathophysiology remain poorly characterized. As a result, diagnosis and critical therapies may be delayed.
methodsWe used DNA microarrays to identify possible diagnostic features of KD. We compared gene expression patterns in the blood of 23 children with acute KD and 18 age-matched febrile children with 3 illnesses that resemble KD.
resultsGenes associated with platelet and neutrophil activation were expressed at higher levels in patients with KD than in patients with acute adenovirus infections or systemic adverse drug reactions, but levels in patients with KD were not higher than those in patients with scarlet fever. Genes associated with B cell activation were also expressed at higher levels in patients with KD than in control subjects. A striking absence of interferon-stimulated gene expression in patients with KD was confirmed in an independent cohort of patients with KD. Using a set of 38 gene transcripts, we successfully predicted the diagnosis for 21 of 23 patients with KD and 7 of 8 patients with adenovirus infection.
conclusionsThese findings provide insight into the molecular features that distinguish KD from other febrile illnesses and support the feasibility of developing novel diagnostic reagents for KD based on the host response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.